环肽1975145-82-4，BK-1361，cyclo(RLsKDK)，化学式：C31H57N11O9

英文名：BK-1361，cyclo(RLsKDK)

CAS：1975145-82-4

供应商：西安凯新生物科技有限公司

化学式：C31H57N11O9

分子量：727.865

密度： 1.46±0.1 g/cm3(Predicted)

酸度系数(pKa)：4.01±0.10(Predicted)

结构式：

反应机理：

BK-1361（BK1361，cyclo-RLsKDK）是一种具有RLsKDK（s=D-丝氨酸）的环肽，其作为ADAM8的有效选择性抑制剂起作用，IC50为120nM，对ADAM 9,10,12没有显示出显着活性。在基于细胞的脱落测定中抑制CD23的脱落，IC50为182nM。 

BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM; displays no significant activity against ADAM 9, 10, 12, 17 , as well as MMP-2, -9, and -14 at 10 uM; inhibit shedding of CD23 with IC50 of 182 nM in cell-based shedding assays, reduces migration/invasion of pancreatic cancer cells and less ERK1/2 and MMP activation, causes change in cell morphology; decreases tumour burden and metastasis of implanted pancreatic tumour cells and provides improved metrics of clinical symptoms and survival in Kras(G12D)-driven mouse model of PDAC.

产品形式：

1.外观为固体/粉末

2.溶于大部分有机溶剂，溶于水

3.纯度标准95+，详情可在线咨询

保存建议：避免反复冻融，避光避湿保存，储液应该立即使用，-20℃以下冰冻。从冰箱取出产品后,置于室温回温至少30min-1h，再开盖，以避免受潮。

同类型试剂：

Cyclo-(D-Tyr-Gly)

Cyclo(-Tyr-Hpro)

cyclo(His-Pro)

cyclo(Val-Val)

Cyclo(-Leu-Pro)

Cyclo(Leu-Tyr)

Cyclo(D-Leu-L-Pro)

Cyclo(D-Phe-L-Pro)

(3-Azidobutyl)cyclohexane

(Azidomethyl)-cyclohexane

1,7-Dioxa-4,10-diazacyclododecane

Cyclo(L-Phe-trans-4-hydroxy-L-Pro)

Cyclo(L-Leu-trans-4-hydroxy-L-Pro)

1,1,3,3,5,5-HexamethylCyclotrisilazane

1,1,3,3,5,5,7,7-OctamethylCyclotetrasilazane

cyclo(Arg-Gly-Asp-D-Tyr-Val)

Cyclo(-Arg-Ala-Asp-D-Phe-Lys)

cyclo(Arg-Gly-Asp-D-Phe-Cys)

Cyclo(-Arg-Gly-Asp-D-Tyr-Lys)

Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro)

Cyclo(-Arg-Ala-Asp-D-Tyr-Lys)

cyclo(Arg-Gly-Asp-d-Phe-Glu)

注意点：仅用于科学研究或者工业应用等非医疗目的，不可用于人类，非药用，非食用

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