【标题速读】【Ncomm】【biological-sciences】【2022年】【12月】

声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。

1.Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.

副乳头至副丘脑通路介导雄性小鼠恐惧诱导的摄食抑制。

2.TAPE-seq is a cell-based method for predicting genome-wide off-target effects of prime editor.

TAPE-seq是一种基于细胞的方法，用于预测素编辑的全基因组脱靶效应。

3.Efficient neural codes naturally emerge through gradient descent learning.

高效的神经代码通过梯度下降学习自然出现。

4.Metagenomic analysis reveals unexplored diversity of archaeal virome in the human gut.

元基因组学分析揭示了人类肠道中未被开发的古细菌病毒群的多样性。

5.Genomics and phenomics of body mass index reveals a complex disease network.

体重指数的基因组学和表型组学揭示了一个复杂的疾病网络。

6.Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies.

动态18F-Pretomanid PET成像在结核性脑膜炎动物模型和人类研究中的应用。

7.Multistep diversification in spatiotemporal bacterial-phage coevolution.

时空细菌-噬菌体协同进化中的多步骤多样化。

8.High-frequency synthetic apomixis in hybrid rice.

杂交水稻中的高频合成apomixis。

9.Ligand recognition and activation of neuromedin U receptor 2.

神经梅素U受体2的配体识别和激活.

10.Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.

针对SARS-CoV-2 Omicron亚型BA.1、BA.2和BA.4/5以及多种沙贝科病毒的广泛中和和保护性纳米抗体。

11.Prediction of designer-recombinases for DNA editing with generative deep learning.

用生成式深度学习预测用于DNA编辑的设计者-重组酶。

12.The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.

脂质翻转酶SLC47A1阻断了新陈代谢对铁锈病的脆弱性。

13.Genome-wide identification of genes required for alternative peptidoglycan cross-linking in Escherichia coli revealed unexpected impacts of β-lactams.

大肠杆菌中替代性肽聚糖交联所需基因的全基因组鉴定揭示了β-内酰胺的意外影响。

14.Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages.

单细胞转录组分析确定了胚胎和新生儿阶段的小鼠心脏分子特征。

15.PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.

PRSS2通过抑制Tsp1重塑肿瘤微环境，刺激肿瘤的生长和发展。

16.Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19.

COVID-19中的单核细胞从先天免疫功能到亲血栓特征的转录重编程。

17.Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats.

植入式壁龛与局部免疫抑制的胰岛异位移植实现了大鼠1型糖尿病的逆转。

18.Arabidopsis γ-H2A.X-INTERACTING PROTEIN participates in DNA damage response and safeguards chromatin stability.

拟南芥γ-H2A.X-反应蛋白参与DNA损伤反应，保障染色质稳定。

19.Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex.

植入小鼠体内的人类皮层器官的多模态监测揭示了与视觉皮层的功能联系。

20.Altered sulfation status of FAM20C-dependent chondroitin sulfate is associated with osteosclerotic bone dysplasia.

FAM20C依赖的硫酸软骨素的硫酸化状态改变与骨硬化性骨发育不良有关。

21.Diverse monogenic subforms of human spermatogenic failure.

人类精子生成障碍的多种单基因亚型。

22.Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease.

药物抑制Lin28促进非酒精性脂肪肝模型的生酮作用并恢复脂质平衡。

23.A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging.

一种用于癌症成像的pH反应性T1-T2双模式MRI造影剂。

24.A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis.

全基因组CRISPR筛查发现WDFY3是巨噬细胞渗出的调节器。

25.Peptidoglycan recycling mediated by an ABC transporter in the plant pathogen Agrobacterium tumefaciens.

植物病原体肿瘤农杆菌中由ABC转运体介导的肽聚糖循环。

26.Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen.

致使脑膜炎的真菌病原体繁殖灵活性的调节基础。

27.Simultaneous profiling of histone modifications and DNA methylation via nanopore sequencing.

通过纳米孔测序对组蛋白修饰和DNA甲基化进行同步分析。

28.Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells.

用于活细胞中基因组成像和操作的可诱导生物分子组合工程。

29.Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues.

阿肯色核中持续的胆碱能-多巴胺能更新是奖励预测线索的基础。

30.An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning.

树突整合和空间学习的频率依赖性控制的星形细胞信号回路。

31.Topographic organization of eye-position dependent gain fields in human visual cortex.

人类视觉皮层中与眼位有关的增益场的地形组织。

32.Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.

在单分子水平上观察穗状变体-ACE2相互作用的力调控热度。

33.Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation.

使用机器人辅助组织微操作解构斑马鱼胚胎的体轴形态发生。

34.A randomized trial of oral gamma aminobutyric acid (GABA) or the combination of GABA with glutamic acid decarboxylase (GAD) on pancreatic islet endocrine function in children with newly diagnosed type 1 diabetes.

口服γ-氨基丁酸（GABA）或GABA与谷氨酸脱羧酶（GAD）组合对新诊断的1型糖尿病儿童的胰岛内分泌功能的随机试验。

35.Thousands of human non-AUG extended proteoforms lack evidence of evolutionary selection among mammals.

数以千计的人类非AUG扩展蛋白形式在哺乳动物中缺乏进化选择的证据。

36.Evolutionary rescue of resistant mutants is governed by a balance between radial expansion and selection in compact populations.

抗性突变体的进化救援受紧凑种群中的径向扩张和选择之间的平衡所支配。

37.Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression.

靶向抗凋亡途径可消除衰老的黑色素细胞并导致痣的消退。

38.Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2.

通过MT1-MMP介导的ACE2的脱落控制SARS-CoV-2的感染。

39.Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease.

葡萄糖的吸收推动了多囊肾的人类类器官芯片模型中的囊肿生成。

40.Exon junction complex shapes the m6A epitranscriptome.

外显子连接复合体塑造了m6A外显子组。

41.Paratype: a genotyping tool for Salmonella Paratyphi A reveals its global genomic diversity.

Paratype：一种副伤寒沙门氏菌A的基因分型工具，揭示了其全球基因组的多样性。

42.Effects of phytoplankton, viral communities, and warming on free-living and particle-associated marine prokaryotic community structure.

浮游植物、病毒群落和气候变暖对自由生活的和与颗粒相关的海洋原核生物群落结构的影响。

43.Reply to: A balanced measure shows superior performance of pseudobulk methods in single-cell RNA-sequencing analysis.

回应： 一个平衡的措施显示了单细胞RNA测序分析中假包络方法的优越性能。

44.A balanced measure shows superior performance of pseudobulk methods in single-cell RNA-sequencing analysis.

一个平衡的措施显示了假包络方法在单细胞RNA测序分析中的优越性能。

45.Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach.

检测蛋白质组学数据中纵向差异表达的基准工具可以建立一个强大的可重复性优化回归方法。

46.A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1.

一种针对SARM1的烟酰胺单核苷酸激活状态的构象特异性纳米抗体。

47.Graph-based pangenomics maximizes genotyping density and reveals structural impacts on fungal resistance in melon.

基于图形的泛基因组学最大限度地提高了基因分型密度，并揭示了结构对瓜类真菌抗性的影响。

48.Cross-kingdom synthetic microbiota supports tomato suppression of Fusarium wilt disease.

跨领域的合成微生物群支持番茄抑制镰刀菌枯萎病。

49.Memory for nonadjacent dependencies in the first year of life and its relation to sleep.

出生后第一年的非相依性记忆及其与睡眠的关系。

50.Divergent roles of herbivory in eutrophying forests.

食草动物在富营养化森林中的不同作用。

51.A method to build extended sequence context models of point mutations and indels.

一种建立点突变和缩进点的扩展序列环境模型的方法。

52.Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations.

MRTF-A/SRF信号介导的肌动蛋白-微管细胞骨架相互作用促进LMNA突变引起的扩张型心肌病。

53.Design of a self-driven probiotic-CRISPR/Cas9 nanosystem for sono-immunometabolic cancer therapy.

设计一个自我驱动的益生菌-CRISPR/Cas9纳米系统，用于声免疫代谢癌症治疗。

54.Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice.

星形胶质细胞放大了神经血管耦合对清醒小鼠新皮质的持续激活作用。

55.Synaptic basis of a sub-second representation of time in a neural circuit model.

神经回路模型中时间的亚秒表征的突触基础。

56.Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration.

在老年性黄斑变性小鼠模型的基因编辑治疗中保障基因组的完整性。

57.Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion.

投射到肌肉间核的中脊5-羟色胺能神经元控制着偏好和厌恶。

58.Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease.

表观基因组范围内的荟萃分析确定了与糖尿病肾病相关的DNA甲基化生物标志物。

59.Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.

调控糖脂代谢和自噬可改善骨髓瘤骨病临床前模型的结果。

60.Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.

SUMO特异性蛋白酶2的缺失通过阻断小鼠肾上腺皮质带状转分化而导致孤立的糖皮质激素缺乏症。

61.Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.

用组合式微滴平台的生物分子凝结物相图。

62.Tiltable objective microscope visualizes selectivity for head motion direction and dynamics in zebrafish vestibular system.

可倾斜物镜观察斑马鱼前庭系统中头部运动方向和动态的选择性。

63.Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling.

钙通透性通道荷尔蒙蛋白对钙信号的光控作用。

64.The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.

UFM1系统通过CYB5R3的ufmylation调控ER-phagy。

65.Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling.

使用Rosetta、AlphaFold和质谱共价标签进行蛋白质复合物预测。

66.Proteome-wide 3D structure prediction provides insights into the ancestral metabolism of ancient archaea and bacteria.

整个蛋白质组的三维结构预测提供了对古代古细菌和细菌的祖先代谢的见解。

67.SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse.

雄性小鼠Sertoli瓣的形成和正常精子生成需要SOX17阳性的睾丸上皮细胞。

68.Sourcing thermotolerant poly(ethylene terephthalate) hydrolase scaffolds from natural diversity.

从自然多样性中寻找耐高温的聚对苯二甲酸乙二醇酯水解酶支架。

69.Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation.

通过单核RNAseq揭示的亨廷顿病少突胶质细胞成熟缺陷可通过补充硫胺素-生物素得到拯救。

70.Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site.

靶向神经氨酸酶活性位点的抗体可抑制具有S245N糖基化位点的H3N2流感病毒。

71.Structure of a RecT/Redβ family recombinase in complex with a duplex intermediate of DNA annealing.

RecT/Redβ家族重组酶与DNA退火的双倍体中间物复合的结构。

72.Molecular mechanism of antibody neutralization of coxsackievirus A16.

柯萨奇病毒A16的抗体中和的分子机制。

73.Machine learning assisted interferometric structured illumination microscopy for dynamic biological imaging.

机器学习辅助的干涉结构照明显微镜用于动态生物成像。

74.Morphological control enables nanometer-scale dissection of cell-cell signaling complexes.

形态学控制使细胞-细胞信号复合体的纳米级剖析成为可能。

75.Exceptional preservation and foot structure reveal ecological transitions and lifestyles of early theropod flyers.

特殊的保存和足部结构揭示了早期恒温动物的生态过渡和生活方式。

76.Combining genome-wide association studies highlight novel loci involved in human facial variation.

结合全基因组关联研究突出了参与人类面部变异的新位点。

77.Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.

支链氨基酸衍生的氮的动态分配支持肾癌的发展。

78.STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity.

STREAMING-标签系统揭示了转录调控因子和转录活动之间的时空关系。

79.Hippocampus as a sorter and reverberatory integrator of sensory inputs.

海马是感觉输入的分拣器和混响集成器。

80.Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.

冈崎片段密封中PCNA对人类Lig1的调节机制。

81.Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY.

大环核苷类抗菌剂的合成及其与MraY的相互作用。

82.Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice.

慢性接触合成食品着色剂Allura Red AC通过小鼠肠道5-羟色胺促进对实验性结肠炎的敏感性。

83.Wood structure explained by complex spatial source-sink interactions.

用复杂的空间源-汇相互作用解释木材结构。

84.Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila.

刺猬介导的肠道-味觉神经元轴控制果蝇的甜味感知。

85.A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits.

15个复杂性状的GWAS和EWAS确定的基因和基因组的比较。

86.Bioenergetics of pollen tube growth in Arabidopsis thaliana revealed by ratiometric genetically encoded biosensors.

拟南芥花粉管生长的生物能量学由比率基因编码的生物传感器揭示。

87.Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke.

内皮细胞调节中风小鼠模型中星形细胞向神经祖细胞的转分化。

88.Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles.

合理设计酶以实现生物催化的Baldwin环化和手性杂环的不对称合成。

89.Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles.

通过突触小泡的聚集对突触传递进行快速和可逆的光遗传学沉默。

90.Climate warming has compounded plant responses to habitat conversion in northern Europe.

气候变暖加剧了欧洲北部植物对栖息地转换的反应。

91.Number of simultaneously acting global change factors affects composition, diversity and productivity of grassland plant communities.

同时作用的全球变化因素的数量影响草原植物群落的组成、多样性和生产力。

92.Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis.

L-薄荷醇靶向转录因子HES1可恢复银屑病模型中角质层细胞的蛋白磷酸酶6。

93.USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity.

USP5-Beclin 1轴推翻了p53依赖性的衰老并驱动Kras诱导的致瘤性。

94.Translation factor eIF5a is essential for IFNγ production and cell cycle regulation in primary CD8+ T lymphocytes.

翻译因子eIF5a对初级CD8+T淋巴细胞的IFNγ产生和细胞周期调节至关重要。

95.Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer.

血清代谢特征揭示了直肠癌患者新辅助化放疗的治疗毒性和反应。

96.Biodiversity stabilizes plant communities through statistical-averaging effects rather than compensatory dynamics.

生物多样性通过统计平均效应而不是补偿性动态稳定植物群落。

97.Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially.

通过连续施加的局部电场在啮齿动物的颞叶癫痫模型中对癫痫病灶进行闭环直接控制。

98.Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS.

链球菌抗体降解酶IdeS和EndoS的广泛底物识别。

99.Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice.

肌肉4EBP1的激活修改了小鼠神经肌肉接头的结构和功能。

100.Chemical reaction-mediated covalent localization of bacteria.

化学反应介导的细菌共价定位。

101.A secreted effector with a dual role as a toxin and as a transcriptional factor.

一种具有毒素和转录因子双重作用的分泌型效应物。

102.Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19.

重症COVID-19恢复期患者的Sars-CoV-2-M蛋白特异性细胞毒性T淋巴细胞功能失调。

103.Detecting and quantifying liquid–liquid phase separation in living cells by model-free calibrated half-bleaching.

通过无模型校准的半漂白检测和量化活细胞中的液-液相分离。

104.Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-κB-inducing kinase in mice.

肝脏neddylation缺失通过诱导小鼠NF-κB诱导性激酶引发致命的肝损伤。

105.Suppression of flavivirus transmission from animal hosts to mosquitoes with a mosquito-delivered vaccine.

用蚊子递送的疫苗抑制黄病毒从动物宿主到蚊子的传播。

106.Sequence-specific capture and concentration of viral RNA by type III CRISPR system enhances diagnostic.

III型CRISPR系统对病毒RNA的序列特异性捕获和浓缩增强了诊断能力。

107.A signal-like role for floral humidity in a nocturnal pollination system.

花卉湿度在夜间授粉系统中的信号类作用。

108.Achieving single nucleotide sensitivity in direct hybridization genome imaging.

在直接杂交基因组成像中实现单核苷酸敏感性。

109.Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence.

多组学识别下降的LRRC15作为COVID-19严重性标志物和疗养中持续的促血栓信号。

110.Sleep-like unsupervised replay reduces catastrophic forgetting in artificial neural networks.

类似睡眠的无监督重放减少了人工神经网络的灾难性遗忘。

111.A unifying Bayesian framework for merging X-ray diffraction data.

合并X射线衍射数据的统一贝叶斯框架。

112.Structural insights into p300 regulation and acetylation-dependent genome organisation.

对p300调节和乙酰化依赖的基因组组织的结构性见解。

113.Bond-selective intensity diffraction tomography.

邦德选择强度的衍射断层扫描。

114.Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development.

Nr6a1控制Hox表达动态，是脊椎动物躯干发育的主要调节器。

115.Accuracy and data efficiency in deep learning models of protein expression.

蛋白质表达的深度学习模型的准确性和数据效率。

116.Estimating diagnostic uncertainty in artificial intelligence assisted pathology using conformal prediction.

利用保形预测估计人工智能辅助病理学的诊断不确定性.

117.Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes.

从未培养的微生物中发现用于基因组编辑的紧凑型Cas9d和HEARO酶。

118.A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors.

黑质-下肢-旁肢通路调控类似疼痛的行为。

119.Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy.

可降解零价铜纳米立方体上的原子分散的金子增强了氧驱动的芬顿样反应，用于有效的正位肿瘤治疗。

120.Microencapsulation and nanowarming enables vitrification cryopreservation of mouse preantral follicles.

微囊化和纳米温控实现了小鼠前卵泡的玻璃化冷冻保存。

121.Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast.

工程酵母的蘑菇源II型灵芝酸的生物合成。

122.In-depth mapping of protein localizations in whole tissue by micro-scaffold assisted spatial proteomics (MASP).

显微支架辅助空间蛋白质组学（MASP）对整个组织中蛋白质定位的深入映射。

123.A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection.

人体呼吸中的结核分枝杆菌指纹可以检测结核病。

124.Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes.

外泌体miR-1304-3p通过激活癌症相关的脂肪细胞促进非裔美国人乳腺癌的进展。

125.Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones.

初次接触SARS-CoV-2变体可引起趋同的表位特异性、免疫球蛋白V基因使用和公共B细胞克隆。

126.St18 specifies globus pallidus projection neuron identity in MGE lineage.

St18在MGE系中指定球状小脑投射神经元的身份。

127.Biodiversity–stability relationships strengthen over time in a long-term grassland experiment.

在长期的草原实验中，生物多样性-稳定性关系随着时间的推移而加强。

128.Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome.

活细胞中DNA-铈纳米复合物的动态组装产生了人工过氧化物酶体。

129.Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens.

从大规模泛癌扰动筛选中发现合成致死的相互作用。

130.Structure of the Acidobacteria homodimeric reaction center bound with cytochrome c.

与细胞色素c结合的酸杆菌同源反应中心的结构。

131.Genetic architecture of heart failure with preserved versus reduced ejection fraction.

保留射血分数与减少射血分数的心力衰竭的遗传结构。

132.Genome of Paspalum vaginatum and the role of trehalose mediated autophagy in increasing maize biomass.

Paspalum vaginatum的基因组和trehalose介导的自噬在增加玉米生物量中的作用。

133.Deep brain stimulation creates informational lesion through membrane depolarization in mouse hippocampus.

深度脑刺激通过小鼠海马体的膜去极化产生信息性病变。

134.Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration.

斑马鱼心脏再生需要激活心外膜的瞬时祖细胞状态。

135.Histone H3.3 deposition in seed is essential for the post-embryonic developmental competence in Arabidopsis.

种子中组蛋白H3.3的沉积对拟南芥胚胎后的发育能力至关重要。

136.Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases.

非传染性炎症性皮肤病病变的空间转录组学景观。

137.BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants.

BA.2和BA.5 omicron与BA.1 omicron和pre-omicron变体的免疫学差异。

138.Functional crosstalk between the cohesin loader and chromatin remodelers.

协同蛋白加载器和染色质重塑器之间的功能串联。

139.CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.

CENP-F依赖的DRP1功能在卵母细胞减数分裂I期间调节APC/C的活性。

140.Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner.

局部组织和激活的Fth1hi中性粒细胞以IL-10依赖的方式加重急性肺损伤的炎症。

141.Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum.

成年小鼠纹状体中组蛋白翻译后修饰的细胞类型特征分析。

142.Clustering of single-cell multi-omics data with a multimodal deep learning method.

用多模态深度学习方法对单细胞多组学数据进行聚类。

143.Gene augmentation prevents retinal degeneration in a CRISPR/Cas9-based mouse model of PRPF31 retinitis pigmentosa.

基因增强可防止基于CRISPR/Cas9的PRPF31视网膜色素变性小鼠模型中的视网膜变性。

144.Microbiome-mediated fructose depletion restricts murine gut colonization by vancomycin-resistant Enterococcus.

微生物体介导的果糖耗竭限制了耐万古霉素的肠球菌在小鼠肠道的定植。

145.Inferring time-varying generation time, serial interval, and incubation period distributions for COVID-19.

推断COVID-19的时变生成时间、序列间隔和孵化期分布。

146.Structure-function studies reveal ComEA contains an oligomerization domain essential for transformation in gram-positive bacteria.

结构-功能研究显示ComEA含有一个对革兰氏阳性菌转化至关重要的寡聚结构域。

147.Immunogenicity and efficacy of fourth BNT162b2 and mRNA1273 COVID-19 vaccine doses; three months follow-up.

第四剂BNT162b2和mRNA1273 COVID-19疫苗的免疫原性和疗效；三个月的随访。

148.Reported sleep duration reveals segmentation of the adult life-course into three phases.

报告的睡眠时间显示，成人的生命历程被分割成三个阶段。

149.Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations.

由类似朊病毒的低复杂度域形成的凝集物具有小世界网络结构和由扩展构象定义的界面。

150.Tumor fractions deciphered from circulating cell-free DNA methylation for cancer early diagnosis.

从循环无细胞DNA甲基化解读肿瘤部分，用于癌症早期诊断。

151.Anomalous inapplicability of nacre-like architectures as impact-resistant templates in a wide range of impact velocities.

在广泛的冲击速度下，珍珠状结构作为抗冲击模板的异常不适用性。

152.Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males.

小鼠表型性状的异体测量的性别差异表明，雌性不是按比例的雄性。

153.Broad misappropriation of developmental splicing profile by cancer in multiple organs.

癌症在多个器官中广泛挪用发育剪接谱。

154.Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America.

欧洲和北美大肠杆菌中延伸谱系头孢菌素抗性基因的动态变化。

155.Regulation of bone homeostasis by MERTK and TYRO3.

MERTK和TYRO3对骨质平衡的调节。

156.Tagging active neurons by soma-targeted Cal-Light.

以体细胞为目标的Cal-Light标记活性神经元.

157.Deep transfer learning enables lesion tracing of circulating tumor cells.

深度迁移学习实现了循环肿瘤细胞的病变追踪。

158.PEAC-seq adopts Prime Editor to detect CRISPR off-target and DNA translocation.

PEAC-seq采用Prime Editor检测CRISPR脱靶和DNA易位。

159.An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics.

通过单核转录组学解决产前晚期人类神经发育的图谱。

160.Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes.

英国生物库外显子中携带新的串联重复突变的位点的全表型关联研究。

161.Different roles of concurring climate and regional land-use changes in past 40 years’ insect trends.

气候和区域土地利用变化在过去40年的昆虫趋势中的不同作用。

162.Structural mechanism of signal transduction in a phytochrome histidine kinase.

植物色素组氨酸激酶中信号转导的结构机制。

163.Ocular tropism of SARS-CoV-2 in animal models with retinal inflammation via neuronal invasion following intranasal inoculation.

SARS-CoV-2在动物模型中的眼球趋向性，通过鼻内接种后的神经元侵袭引起视网膜炎症。

164.Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms.

多发性硬化症严重程度的分子模型确定致病机制的异质性。

165.Bioenergetic control of soil carbon dynamics across depth.

跨越深度的土壤碳动力学的生物能量控制。

166.SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice.

SIRT7通过调控小鼠棕色脂肪组织功能抑制能量消耗和产热。

167.PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.

PRDM1/BLIMP1通过调节肝癌细胞的USP22-SPI1-PD-L1轴诱导癌症免疫规避。

168.Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer.

在EGFR突变的肺癌中，RhoA增强了脑转移的生长和奥希姆替尼的抗性。

169.Effectiveness of ChAdOx1-S COVID-19 booster vaccination against the Omicron and Delta variants in England.

英国ChAdOx1-S COVID-19加强型疫苗对Omicron和Delta变种的有效性。

170.A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins.

一个广泛分布的真核生物和细菌去泛素酶家族，与疱疹病毒大包膜蛋白有关。

171.Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments.

Cryo-electron tomography揭示了对Dynamin-like EHD filaments的膜重塑模式的结构见解。

172.Myeloid cells promote interferon signaling-associated deterioration of the hematopoietic system.

髓细胞促进干扰素信号相关的造血系统的恶化。

173.A glutamate receptor C-tail recruits CaMKII to suppress retrograde homeostatic signaling.

一个谷氨酸受体的C-尾巴招募CaMKII以抑制逆行的同源信号。

174.Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility.

激活多药耐药性外排泵的替代运输模式，以赋予化学药敏性。

175.The B-type response regulator GmRR11d mediates systemic inhibition of symbiotic nodulation.

B型反应调节器GmRR11d介导了对共生结核的系统性抑制。

176.Structure of nucleosome-bound human PBAF complex.

核糖体结合的人类PBAF复合物的结构。

177.Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.

靶向心肌细胞ADAM10外域脱落促进心肌梗死后早期生存。

178.A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma.

多表型分析揭示了基底细胞癌的19个易感位点和鳞状细胞癌的15个易感位点。

179.Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia.

医疗记录中的因果推断和互补系统药理学用于二甲双胍药物再利用，面向痴呆症。

180.CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation.

CRL2ZER1/ZYG11B识别小的N端残基进行降解。

181.An HSV-1-H129 amplicon tracer system for rapid and efficient monosynaptic anterograde neural circuit tracing.

HSV-1-H129扩增子示踪系统用于快速、高效的单突触前向神经回路追踪。

182.Sirt6 attenuates chondrocyte senescence and osteoarthritis progression.

Sirt6减弱软骨细胞的衰老和骨关节炎的进展。

183.Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity.

健康人类肾脏的单细胞分析揭示了基于性别的转录程序和组织特异性免疫的特征。

184.Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding.

Spatial-ID：一种通过转移学习和空间嵌入进行空间解析转录组学的细胞分型方法。

185.A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis.

一种富含棕色脂肪的脂肪因子Adissp控制脂肪生热和葡萄糖稳态。

186.Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas.

线粒体功能障碍诱导小鼠视网膜中ALK5-SMAD2介导的血管减退和动静脉畸形。

187.The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi.

建立COPD器官来研究宿主与病原体的相互作用，揭示了SARS-CoV-2在支气管中的病毒适应性增强。

188.Regulating voltage-gated ion channels with nanobodies.

用纳米抗体调节电压门控离子通道。

189.Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis.

第2组先天性淋巴细胞通过肺-肠轴的成熟和特化。

190.Visualizing the transiently populated closed-state of human HSP90 ATP binding domain.

可视化人类HSP90 ATP结合域的瞬时填充封闭状态。

191.Interpretable and tractable models of transcriptional noise for the rational design of single-molecule quantification experiments.

用于合理设计单分子定量实验的可解释和可操作的转录噪音模型。

192.The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes.

转录因子DDIT3是骨髓增生异常综合征中红细胞生成障碍的一个潜在驱动因素。

193.Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody.

用功能化纳米抗体对CaVβ1相关电压依赖性钙通道进行选择性翻译后抑制。

194.High-throughput robust single-cell DNA methylation profiling with sciMETv2.

sciMETv2的高通量单细胞DNA甲基化分析。

195.Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa.

铜绿假单胞菌海藻酸盐生产和生物膜附着所需的AlgKX修饰和分泌复合物的结构。

196.Limited conservation in cross-species comparison of GLK transcription factor binding suggested wide-spread cistrome divergence.

在GLK转录因子结合的跨物种比较中，有限的保护表明了广泛的组群分化。

197.Suicidal chemotaxis in bacteria.

细菌的自杀性趋化作用。

198.SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling.

SARS-CoV-2穗状病毒通过整合素和TGF-β信号传导引发屏障功能障碍和血管渗漏。

199.Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia.

免疫基因损失与海马雄性怀孕同时发生，tlx1的突变伴随着功能性无脾症。

200.TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti.

TBX2指定并维持内毛和支持细胞在科尔蒂器官的命运。

201.Noradrenergic signaling mediates cortical early tagging and storage of remote memory.

北肾上腺素能信号介导皮质早期标记和远程记忆的存储。

202.Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice.

在小鼠中自主检测和抑制病毒的抗病毒免疫系统工程。

203.Parvalbumin basket cell myelination accumulates axonal mitochondria to internodes.

副白蛋白篮细胞髓鞘化将轴突线粒体积累到节间。

204.Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators.

对人类肠道细菌Eggerthella lenta的遗传操作揭示了一个广泛的转录调节器家族。

205.Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes.

包括H17/18亚型在内的人类广泛中和甲型流感血凝素干细胞特异性抗体的结构基础。

206.Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation.

催化受损的ATP磷酸核苷转移酶变体的异生拯救将蛋白质动力学与活性位点静电预组织联系起来。

207.Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.

Meteorin-like是一种可注射的肽，可以通过免疫驱动的纤维/脂肪生成祖细胞信号来增强老年肌肉的再生能力。

208.Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.

基于线粒体血铜氧化酶的保守异构体的结构差异识别抗生素。

209.An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae.

一种RNA海绵控制霍乱弧菌的法定人数感应动态和生物膜的形成。

210.Recent speciation associated with range expansion and a shift to self-fertilization in North American Arabidopsis.

与北美拟南芥的范围扩张和向自花授精转变有关的最近的物种变化。

211.Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation.

细胞内galectin-3是一种脂多糖传感器，通过mTORC1的激活促进糖酵解。

212.Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program.

在NHLBI TOPMed计划中，全基因组测序确定了有助于血液学特征的结构变异。

213.Conserved degronome features governing quality control associated proteolysis.

掌管质量控制相关的蛋白质分解的保守的degronome特征。

214.Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine.

发现了一个广泛的细菌ABC转运体，其结构对麦角硫因具有特异性。

215.Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.

同源蛋白TRIM2和TRIM3的不同自我关联属性调节其E3连接酶的活性。

216.Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation.

通过IL18受体和Na-Cl共转运体的不同IL18信号传递区分了产热和葡萄糖代谢的调节。

217.Neural precursor cells tune striatal connectivity through the release of IGFBPL1.

神经前体细胞通过释放IGFBPL1调控纹状体的连接性。

218.Slow growing behavior in African trypanosomes during adipose tissue colonization.

非洲锥虫在脂肪组织定植期间的缓慢生长行为。

219.The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii.

蛋白磷酸酶2A全酶是弓形虫的淀粉代谢和卤虫分化的关键调节因子。

220.The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction.

色氨酸-NAD+途径在严重营养不良诱发肝功能障碍的小鼠模型中的作用。

221.Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infection.

鉴定与病毒感染早期阶段IFN-γ反应升高有关的人类衰竭CD8+T细胞的祖先。

222.Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer.

肿瘤和免疫细胞的多区域单细胞剖析揭示了肝癌的稳定锁定特征。

223.pGlycoQuant with a deep residual network for quantitative glycoproteomics at intact glycopeptide level.

pGlycoQuant与深度残留网络，用于完整糖肽水平的定量糖蛋白组学。

224.CD1a promotes systemic manifestations of skin inflammation.

CD1a促进皮肤炎症的系统性表现。

225.Breast cancer prevention by short-term inhibition of TGFβ signaling.

通过短期抑制TGFβ信号传导预防乳腺癌.

226.Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A.

新辅助性乳腺癌的磷蛋白组学分析表明，对紫杉醇敏感性的增加是由CDK4和filamin A驱动的。

227.GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression.

头内侧被盖核的GABA能神经元对快速眼动睡眠抑制至关重要。

228.Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.

上皮细胞TGFβ参与生长因子信号以规避细胞凋亡并驱动具有攻击性特征的肠道肿瘤发生。

229.Population fluctuations and synanthropy explain transmission risk in rodent-borne zoonoses.

种群波动和协同作用解释了啮齿动物传染病的传播风险。

230.An in silico method to assess antibody fragment polyreactivity.

一种评估抗体片段多反应性的硅方法

231.Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases.

量化转录物水平在介导DNA甲基化对复杂性状和疾病影响中的作用。

232.Deconstruction of a hypothalamic astrocyte-white adipocyte sympathetic axis that regulates lipolysis in mice.

解构调节小鼠脂肪分解的下丘脑星形细胞-白脂肪细胞交感神经轴。

233.Dynamic control of decision and movement speed in the human basal ganglia.

人类基底神经节对决策和运动速度的动态控制。

234.Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase.

III-E型CRISPR核酸酶-蛋白酶Craspase的非自身RNA激活蛋白酶活性的结构基础。

235.The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling.

发情周期通过孕酮信号调节早期生活逆境对小鼠回避行为的影响。

236.Backbone amides are determinants of Cl− selectivity in CLC ion channels.

骨架酰胺是CLC离子通道中Cl-选择性的决定因素。

237.SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing.

SESAME催化的H3T11磷酸化抑制了Dot1催化的H3K79me3以调节自噬和端粒沉默。

238.The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families.

辅助结构域在调控CHD4活性方面的作用表明酶家族之间的机制共性。

239.Increases in reef size, habitat and metacommunity complexity associated with Cambrian radiation oxygenation pulses.

与寒武纪辐射含氧量脉冲有关的珊瑚礁规模、生境和元群落复杂性的增加。

240.New globally distributed bacterial phyla within the FCB superphylum.

FCB超门内新的全球分布的细菌门类。

241.Multiple drivers and lineage-specific insect extinctions during the Permo–Triassic.

在近三叠纪期间，多种驱动因素和特定品系的昆虫灭绝。

242.Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.

RNA结合蛋白相互作用组的特征揭示了MYC扩增的髓母细胞瘤的背景特异性转录后景观。

243.DAP5 enables main ORF translation on mRNAs with structured and uORF-containing 5′ leaders.

DAP5使具有结构化和含uORF的5′领导的mRNA上的主ORF翻译。

244.Slowest possible replicative life at frigid temperatures for yeast.

酵母在低温下可能的最慢复制生命。

245.The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.

胰岛素受体的动态集群是其信号传导的基础，在胰岛素抵抗中被破坏。

246.Gut microbiome-wide association study of depressive symptoms.

抑郁症状的全肠道微生物组关联研究。

247.Food abundance in men before puberty predicts a range of cancers in grandsons.

青春期前男性的食物丰度可预测孙子的一系列癌症。

248.Next generation genetically encoded fluorescent sensors for serotonin.

下一代5-羟色胺的基因编码荧光传感器。

249.Ruminant inner ear shape records 35 million years of neutral evolution.

反刍动物内耳形状记录了3500万年的中性进化。

250.LY6D marks pre-existing resistant basosquamous tumor subpopulations.

LY6D标记预先存在的抗性基底细胞肿瘤亚群。

251.The gut microbiota and depressive symptoms across ethnic groups.

肠道微生物群和不同种族群体的抑郁症状。

252.The overlapping burden of the three leading causes of disability and death in sub-Saharan African children.

撒哈拉以南非洲儿童残疾和死亡的三个主要原因的重叠负担。

253.Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.

TRPV2 结构和功能的大麻素非大麻二酚位点调制。

254.Planar aggregation of the influenza viral fusion peptide alters membrane structure and hydration, promoting poration.

流感病毒融合肽的平面聚集改变了膜结构和水合作用，促进了孔化。

255.SepN is a septal junction component required for gated cell–cell communication in the filamentous cyanobacterium Nostoc.

SepN是丝状蓝藻中门控细胞-细胞通讯所需的隔膜连接组件。

256.The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing.

昼夜钟通过调控树突状细胞抗原处理影响T细胞对疫苗接种的反应。

257.Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.

抗病毒因子APOBEC3G识别序列特异性RNA的结构基础。

258.Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus.

单细胞测序显示红斑狼疮皮肤病变的细胞异质性。

259.Proteogenomic characterization of MiT family translocation renal cell carcinoma.

MiT家族易位肾细胞癌的蛋白质基因组学特征。

260.Pexophagy suppresses ROS-induced damage in leaf cells under high-intensity light.

Pexophagy抑制高强度光照下叶细胞的ROS诱导损伤。

261.Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects.

快速眼动睡眠行为障碍的全基因组关联研究确定了多基因风险和大脑表达效应。

262.Impact of international travel and diarrhea on gut microbiome and resistome dynamics.

国际旅行和腹泻对肠道微生物组和抗性组动态的影响。

263.Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

组织和液体活检分析揭示了乳腺癌中趋同的肿瘤演变和治疗规避。

264.Federated learning enables big data for rare cancer boundary detection.

联合学习使大数据用于罕见癌症边界检测。

265.Single-shot self-supervised object detection in microscopy.

显微镜下的单次自监督物体检测。

266.Self-assembling nanofibrous bacteriophage microgels as sprayable antimicrobials targeting multidrug-resistant bacteria.

自组装的纳米纤维状噬菌体微凝胶作为可喷涂的抗菌剂，针对多药耐药菌。

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