【标题速读】【Ncomm】【biological-sciences】【2022年】【5月】

声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。

1.Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3SPOP E3 ligase in cancer cells.

Neddylation抑制通过靶向CRL3SPOP E3连接酶诱导癌细胞对谷氨酰胺的吸收和代谢。

2.STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer.

STING激动剂可重新规划肿瘤相关巨噬细胞，并克服BRCA1缺陷的乳腺癌模型中对PARP抑制的抵抗。

3.The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness.

内置 Rbx1 neddylation-Cullin-RING-Ligase 蛋白对于维持调节性 T 细胞适应性至关重要。

4.Trophic position of Otodus megalodon and great white sharks through time revealed by zinc isotopes.

锌同位素揭示了巨齿鲨和大白鲨在时间上的营养地位。

5.Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity.

生物分子凝聚物的动态停滞和老化受低复杂度结构、RNA和生化活动的调控。

6.Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen.

对医院患者肺炎克雷伯氏菌感染的基因组剖析揭示了对机会主义病原体的见解。

7.Mapping the cardiac vascular niche in heart failure.

绘制心力衰竭中的心脏血管龛。

8.Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.

人A2ML1的低温电镜结构阐明了A2M家族的蛋白酶抑制机制。

9.Structural variant-based pangenome construction has low sensitivity to variability of haplotype-resolved bovine assemblies.

基于结构变异的pangenome构建对解决了单倍型的牛集合体的变异性具有低敏感性。

10.P-selectin mobility undergoes a sol-gel transition as it diffuses from exocytosis sites into the cell membrane.

P-选择素的流动性经历了溶胶-凝胶的转变，因为它从细胞外分泌部位扩散到细胞膜。

11.Dosage-sensitive miRNAs trigger modulation of gene expression during genomic imbalance in maize.

剂量敏感的miRNA在玉米基因组失衡期间引发基因表达的调控。

12.A framework for reconstructing SARS-CoV-2 transmission dynamics using excess mortality data.

利用超额死亡数据重建SARS-CoV-2传播动态的框架。

13.BRD4 promotes resection and homology-directed repair of DNA double-strand breaks.

BRD4促进DNA双链断裂的切除和同源定向修复。

14.Modular (de)construction of complex bacterial phenotypes by CRISPR/nCas9-assisted, multiplex cytidine base-editing.

通过CRISPR/nCas9辅助的多重胞苷碱基编辑，对复杂细菌表型进行模块化（去）构建。

15.Computationally designed hyperactive Cas9 enzymes.

计算设计的超活性Cas9酶。

16.Multicenter phase II trial of Camrelizumab combined with Apatinib and Eribulin in heavily pretreated patients with advanced triple-negative breast cancer.

Camrelizumab联合Apatinib和Eribulin在重度预处理的晚期三阴性乳腺癌患者中的多中心II期试验。

17.Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure.

用VHH体内抗体阻断phospholamban可增强心力衰竭的收缩性和放松性。

18.Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling.

肥大细胞中PAF-AH2产生的Omega-3脂肪酸环氧化物调节肺血管重塑。

19.Open-source personal pipetting robots with live-cell incubation and microscopy compatibility.

具有活细胞孵化和显微镜兼容性的开源个人移液机器人。

20.A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA.

一个与癌症相关的RNA聚合酶III身份驱动snaR-A非编码RNA的强健转录和表达。

21.Identification of positive and negative regulators of antiviral RNA interference in Arabidopsis thaliana.

鉴定拟南芥中抗病毒RNA干扰的正负调节器。

22.Switches, stability and reversals in the evolutionary history of sexual systems in fish.

鱼类性系统进化史中的切换、稳定和逆转。

23.Myriapod genomes reveal ancestral horizontal gene transfer and hormonal gene loss in millipedes.

Myriapod genomes揭示了千足虫的祖先水平基因转移和荷尔蒙基因损失。

24.Cellular and genetic drivers of RNA editing variation in the human brain.

人脑中RNA编辑变异的细胞和遗传驱动因素。

25.CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context.

CRISPR/Cas9 gRNA的活性取决于自由能变化和目标PAM背景。

26.Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity.

恒河猴的长期乙肝病毒感染需要抑制宿主免疫力。

27.Stochastic expression of invasion genes in Plasmodium falciparum schizonts.

恶性疟原虫裂殖体中侵袭基因的随机表达.

28.A lncRNA signature associated with tumor immune heterogeneity predicts distant metastasis in locoregionally advanced nasopharyngeal carcinoma.

与肿瘤免疫异质性相关的lncRNA签名可预测局部区域晚期鼻咽癌的远处转移。

29.Transmission of SARS-CoV-2 from humans to animals and potential host adaptation.

SARS-CoV-2从人到动物的传播及潜在的宿主适应性。

30.Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.

针对SARS-CoV-2 Omicron变体的交叉反应性免疫在曾患COVID-19或MIS-C的小儿患者中很低。

31.Improving recombinant protein production by yeast through genome-scale modeling using proteome constraints.

利用蛋白质组的约束条件，通过基因组规模的建模来改进酵母的重组蛋白生产。

32.Molecular encoding and synaptic decoding of context during salt chemotaxis in C. elegans.

秀丽亚马逊的盐类趋化过程中上下文的分子编码和突触解码。

33.Activation of Nkx2.5 transcriptional program is required for adult myocardial repair.

激活Nkx2.5转录程序是成人心肌修复的需要。

34.Structural basis for broad anti-phage immunity by DISARM.

DISARM的广泛抗噬菌体免疫的结构基础。

35.Histone functions as a cell-surface receptor for AGEs.

组蛋白作为AGEs的细胞表面受体的功能。

36.PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling.

PI(18:1/18:1)是一种SCD1衍生的脂质因子，可限制压力信号的传递。

37.SpotClean adjusts for spot swapping in spatial transcriptomics data.

SpotClean调整了空间转录组学数据中的斑点互换。

38.Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles.

阿尔茨海默病神经纤维缠结中Tau异构体的流畅分子混合。

39.Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy.

用于囊性纤维化治疗的基因特异性无义介导的mRNA衰变靶点。

40.Nitrogen represses haustoria formation through abscisic acid in the parasitic plant Phtheirospermum japonicum.

氮气通过赤霉酸抑制寄生植物Phtheirospermum japonicum的毛细管形成。

41.Automated vitrification of cryo-EM samples with controllable sample thickness using suction and real-time optical inspection.

利用吸力和实时光学检查，对冷冻电子显微镜样品进行自动玻璃化，样品厚度可控。

42.Rewritable two-dimensional DNA-based data storage with machine learning reconstruction.

可重写的基于DNA的二维数据存储与机器学习重建。

43.Prosocial correlates of transformative experiences at secular multi-day mass gatherings.

在世俗的多日群众集会中，变革性经历的亲社会相关因素。

44.Complexity of biological scaling suggests an absence of systematic trade-offs between sensory modalities in Drosophila.

生物缩放的复杂性表明果蝇的感觉模式之间缺乏系统的权衡。

45.RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation.

在Aicardi-Goutières综合征中发生突变的RNase H2解决了共同转录的R环以防止DNA断裂和炎症。

46.Insights into methionine S-methylation in diverse organisms.

对不同生物体中蛋氨酸S-甲基化的深入了解。

47.An integral genomic signature approach for tailored cancer therapy using genome-wide sequencing data.

利用全基因组测序数据进行定制化癌症治疗的整体基因组特征方法。

48.Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions.

原始肠管的单细胞染色质剖析揭示了线型命运决定的调控动态。

49.Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2.

Omicron BA.1对BA.2和BA.3 SARS-CoV-2的交叉中立化。

50.Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice.

多组学揭示了小鼠减肥和体重恢复期间脂肪组织中肥胖相关的免疫细胞表型的持久性。

51.The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase.

长非编码RNA ADIPINT通过丙酮酸羧化酶调控人类脂肪细胞的代谢。

52.Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission.

表达人PAI-1的转基因按蚊损害了疟疾传播。

53.Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project.

西湖区中国人生物库（WBBC）试点项目中10376人的基因组分析。

54.A topological refactoring design strategy yields highly stable granulopoietic proteins.

一种拓扑重构设计策略产生了高度稳定的粒细胞蛋白。

55.Locomotion-induced ocular motor behavior in larval Xenopus is developmentally tuned by visuo-vestibular reflexes.

幼年Xenopus的运动诱导的眼球运动行为在发育过程中受到视觉-前庭反射的调整。

56.SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5.

SARS-CoV-2 ORF7a有力地抑制了宿主因子SERINC5的抗病毒作用。

57.SARS-CoV-2 accessory proteins reveal distinct serological signatures in children.

SARS-CoV-2的附属蛋白显示了儿童中不同的血清学特征。

58.Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy.

骨骼肌卫星细胞的耗竭减轻了肌肉萎缩症的病理变化。

59.Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation.

同源ATP1A1结合诱导激活素A的分泌，促进肿瘤细胞的EMT和肌成纤维细胞的激活。

60.Combining rapid antigen testing and syndromic surveillance improves community-based COVID-19 detection in a low-income country.

结合快速抗原检测和综合症监测，改善低收入国家的社区COVID-19检测。

61.The case for increasing diversity in tissue-based functional genomics datasets to understand human disease susceptibility.

增加基于组织的功能基因组学数据集的多样性以了解人类疾病易感性的案例。

62.Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.

用高选择性的抑制剂针对双特异性的酪氨酸磷酸化调节激酶2来治疗前列腺癌。

63.The potential of polygenic scores to improve cost and efficiency of clinical trials.

多基因评分在提高临床试验的成本和效率方面的潜力。

64.Mutational signatures are markers of drug sensitivity of cancer cells.

突变特征是癌细胞药物敏感性的标志。

65.Peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche.

肽纳米毯阻碍了成纤维细胞的激活和随后转移前龛的形成。

66.O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.

O-GlcNAc修饰的leucyl-tRNA合成酶1整合了亮氨酸和葡萄糖的可用性以调节mTORC1和亮氨酸的代谢命运。

67.Serotonin limits generation of chromaffin cells during adrenal organ development.

羟色胺限制了肾上腺器官发育过程中绒毛细胞的生成。

68.Biogenesis of a bacterial metabolosome for propanediol utilization.

利用丙二醇的细菌代谢体的生物生成。

69.Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

嗅觉神经元对GPCR特性和活性的转录适应。

70.Molecular mechanism of the wake-promoting agent TAK-925.

促醒剂TAK-925的分子机制。

71.Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron microtomography and volume electron microscopy.

通过相关的体内生理学、同步辐射显微镜和体积电子显微镜对脑组织进行功能和多尺度三维结构调查。

72.Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain.

细胞类型特异性生物素标记在体内解决了小鼠大脑中区域神经元和星形细胞蛋白质组的差异。

73.A high-throughput multiparameter screen for accelerated development and optimization of soluble genetically encoded fluorescent biosensors.

用于加速开发和优化可溶性基因编码荧光生物传感器的高通量多参数筛选。

74.Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes.

人类冠状病毒OC43尖峰的抗原结构揭示了暴露和闭塞的中和表位。

75.Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury.

硫酸软骨素蛋白聚糖通过TLR4在脊髓损伤的啮齿动物模型中防止免疫细胞表型转换和炎症解决。

76.Dynamic stiffening of the flagellar hook.

鞭毛钩的动态变硬。

77.The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies.

复制依赖性组蛋白基因的3′Pol II停顿是由Mediator通过Cajal体与组蛋白基因座体的关联来调节的。

78.The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer.

Cdc7-Dbf4激酶对MCM2-7双六聚体的定向和磷酸化的结构基础。

79.Seeking patterns of antibiotic resistance in ATLAS, an open, raw MIC database with patient metadata.

在ATLAS中寻找抗生素耐药性模式，这是一个开放的、带有病人元数据的原始MIC数据库。

80.Exact simulation of pigment-protein complexes unveils vibronic renormalization of electronic parameters in ultrafast spectroscopy.

颜料-蛋白质复合物的精确模拟揭示了超快光谱学中电子参数的振子重正化。

81.Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration.

非酒精性脂肪性肝炎和减肥手术对肝脏和脂肪组织线粒体生物生成和呼吸的影响。

82.Predicting cancer prognosis and drug response from the tumor microbiome.

从肿瘤微生物组预测癌症的预后和药物反应。

83.Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination.

两剂mRNA疫苗接种后老年人对SARS-CoV-2变体的合格免疫反应.

84.Robust temporal map of human in vitro myelopoiesis using single-cell genomics.

利用单细胞基因组学绘制人类体外骨髓造血的稳健时间图。

85.Mothers with higher twinning propensity had lower fertility in pre-industrial Europe.

在工业化前的欧洲，具有较高双胞胎倾向的母亲的生育率较低。

86.A framework to efficiently describe and share reproducible DNA materials and construction protocols.

一个有效描述和分享可重复的DNA材料和构建协议的框架。

87.The RNA-bound proteome of MRSA reveals post-transcriptional roles for helix-turn-helix DNA-binding and Rossmann-fold proteins.

MRSA的RNA结合蛋白组揭示了螺旋转螺旋DNA结合和罗斯曼折叠蛋白的转录后作用。

88.Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction.

Anoctamin 1通过耦合Cl-通道激活和RANKL-RANK信号转导来控制骨吸收。

89.An in vivo gene amplification system for high level expression in Saccharomyces cerevisiae.

酵母菌高水平表达的体内基因扩增系统。

90.Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.

来自低温电镜集合分析的Vanilloid依赖的TRPV1开放轨迹。

91.Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.

译码器合成聚合酶Rev1的核苷酸识别机制。

92.Exceptional parallelisms characterize the evolutionary transition to live birth in phrynosomatid lizards.

异常的平行性是phrynosomatid蜥蜴向活产的进化过渡的特征。

93.Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols.

阿片类受体和其他人类GPCRs在工程化生产人类甾醇的酵母中的功能表达。

94.Auditory processing remains sensitive to environmental experience during adolescence in a rodent model.

在啮齿动物模型中，听觉处理对青少年时期的环境经验仍然敏感。

95.Off-season RSV epidemics in Australia after easing of COVID-19 restrictions.

放宽COVID-19限制后澳大利亚的RSV淡季流行。

96.Addressing the socioeconomic divide in computational modeling for infectious diseases.

应对传染病计算模型中的社会经济鸿沟。

97.Metabolic regulation by the intestinal metformin-AMPK axis.

肠道二甲双胍-AMPK轴的代谢调节。

98.Comments on identifying causal relationships in nonlinear dynamical systems via empirical mode decomposition.

关于通过经验模式分解识别非线性动态系统中的因果关系的评论.

99.Reply To: Comments on identifying causal relationships in nonlinear dynamical systems via empirical mode decomposition.

Reply To： 关于通过经验模式分解识别非线性动力系统中的因果关系的评论。

100.Signal requirement for cortical potential of transplantable human neuroepithelial stem cells.

移植的人类神经上皮干细胞的皮质潜力的信号要求。

101.p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis.

表达胎儿基因特征的p53野生型结直肠癌细胞与转移和预后不良有关。

102.Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning.

通过RNA速度和深度学习揭示细胞周期基因调控动态。

103.The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.

不同配体对毒蕈碱受体M4R的非常规激活.

104.Multisensory task demands temporally extend the causal requirement for visual cortex in perception.

多感官任务需求在时间上扩展了视觉皮层在感知方面的因果要求。

105.Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy.

细胞外波形蛋白模拟VEGF，是抗血管生成免疫疗法的目标。

106.Structural insights into the mechanism of archaellar rotational switching.

对弓形体旋转切换机制的结构性见解。

107.Synthetic lethality between TP53 and ENDOD1.

TP53和ENDOD1之间的合成致死性。

108.Origins of direction selectivity in the primate retina.

灵长类动物视网膜中方向选择性的起源。

109.ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries.

利用合成肽库评估体内主动脉瘤的ADAMTS4特异性MR探针。

110.A genetic engineering strategy for editing near-infrared-II fluorophores.

编辑近红外-II型荧光团的基因工程策略。

111.Complex dynamics in a synchronized cell-free genetic clock.

同步的无细胞遗传钟中的复杂动态。

112.Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.

心脏yanodine受体门控的分子基础解释了功能获得和丧失的突变机制。

113.Limiting motorboat noise on coral reefs boosts fish reproductive success.

限制珊瑚礁上的摩托艇噪音可提高鱼类的繁殖成功率。

114.Insights into the client protein release mechanism of the ATP-independent chaperone Spy.

对ATP非依赖性伴侣蛋白Spy的客户蛋白释放机制的见解。

115.Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.

抑制CDK2和Cyclin A复合物导致癌细胞中CDK2的自噬性降解。

116.Automated next-generation profiling of genomic alterations in human cancers.

人类癌症中基因组改变的自动化下一代分析。

117.Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation.

蛋白质组分配与葡萄糖限制下的酿酒酵母的特定生长速度呈线性变化。

118.Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling.

果蝇气管重塑过程中对祖细胞繁殖的代谢控制。

119.A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data.

基于单核RNA测序数据空间重建的花分生组织三维基因表达图谱。

120.Codon-specific Ramachandran plots show amino acid backbone conformation depends on identity of the translated codon.

特定密码子的拉马钱德兰图显示氨基酸骨架的构象取决于翻译密码子的身份。

121.Reply to “Marine abundance and its prehistoric past in the Baltic”.

对 "波罗的海的海洋丰度及其史前历史 "的答复。

122.Dynamic character displacement among a pair of bacterial phyllosphere commensals in situ.

一对细菌植物圈共生体在原地的动态特征位移。

123.Engineered Cas12i2 is a versatile high-efficiency platform for therapeutic genome editing.

工程化的Cas12i2是治疗性基因组编辑的多功能高效平台。

124.Structural rearrangements allow nucleic acid discrimination by type I-D Cascade.

结构重排允许I-D型级联的核酸辨别。

125.Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis.

纳米粒子增强放疗与PD-L1阻断协同作用，限制手术后癌症复发和转移。

126.Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC.

孔隙阻断剂1PBC对氯通道TMEM16A的抑制机制。

127.RNA supply drives physiological granule assembly in neurons.

RNA供应驱动神经元中的生理性颗粒组装。

128.Topography-induced large-scale antiparallel collective migration in vascular endothelium.

拓扑结构诱导的血管内皮细胞大规模反平行集体迁移。

129.Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment.

线粒体钙离子单体稳定化在复合体I损伤期间保持能量平衡。

130.Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.

通过低温电镜揭示C9ORF72-ALS/FTD相关的聚PR和聚GR蛋白对核糖体的抑制。

131.Frequency modulation of a bacterial quorum sensing response.

细菌法定人数感应反应的频率调节。

132.The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation.

泛素连接酶Cul5调控CD4+T细胞命运选择和过敏性炎症。

133.The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells.

磷酸酶PTEN将血小板与小鼠T滤泡辅助细胞的免疫调节功能联系起来。

134.A truncated anti-CRISPR protein prevents spacer acquisition but not interference.

一种截短的抗CRISPR蛋白能阻止间隔物的获得，但不能阻止干扰。

135.Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro.

广谱CRISPR介导的体外SARS-CoV-2变体和地方性冠状病毒的抑制。

136.BMP4 drives primed to naïve transition through PGC-like state.

BMP4通过PGC样态驱动初生到幼稚的转变。

137.C. elegans enteric motor neurons fire synchronized action potentials underlying the defecation motor program.

秀丽隐士的肠道运动神经元发射同步的动作电位，这是排便运动程序的基础。

138.RNP components condense into repressive RNP granules in the aging brain.

衰老的大脑中RNP成分凝聚成压抑性RNP颗粒。

139.Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.

抑制线粒体复合体I可逆转NOTCH1驱动的T细胞急性淋巴细胞白血病的代谢重编程。

140.Multiplex base- and prime-editing with drive-and-process CRISPR arrays.

用驱动和处理CRISPR阵列进行多重碱基和引物编辑。

141.Optogenetic manipulation and photoacoustic imaging using a near-infrared transgenic mouse model.

利用近红外转基因小鼠模型进行光遗传学操作和光声成像。

142.SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity.

SARS-CoV-2感染导致呼吸道和外周血的免疫反应，提示疾病的严重性机制。

143.RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer.

RNA剪接是肿瘤细胞可塑性的关键媒介，也是结直肠癌的治疗弱点。

144.Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides.

胰腺KATP通道受核苷酸调控机制的结构见解。

145.Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1.

神经元过度兴奋促使神经纤维瘤病-1模型中的中枢和外周神经系统肿瘤的发展。

146.Plant beta-diversity across biomes captured by imaging spectroscopy.

成像光谱学捕获的跨生物群落的植物β多样性。

147.Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine.

麻醉剂dyclonine抑制TRPV3通道的结构机制。

148.Templated folding of the RTX domain of the bacterial toxin adenylate cyclase revealed by single molecule force spectroscopy.

单分子力谱学揭示细菌毒素腺苷酸环化酶RTX结构域的模板化折叠。

149.A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.

一种通过调控NRF2信号通路防止视网膜瘢痕的生物功能聚合物。

150.Modulation of biological motion perception in humans by gravity.

重力对人类生物运动感知的调控。

151.Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients.

不同的热点p53突变体发挥着不同的表型，并预测结直肠癌患者的结局。

152.PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression.

PRRX1是基质成纤维细胞的主转录因子，用于肌成纤维细胞系的进展。

153.TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signalling.

TUBB4A与MYH9相互作用，在细胞迁移过程中保护细胞核，并通过GSK3β/β-catenin信号传导促进前列腺癌。

154.Shielding of actin by the endoplasmic reticulum impacts nuclear positioning.

内质网对肌动蛋白的屏蔽影响核定位。

155.Elimination of human rabies in Goa, India through an integrated One Health approach.

印度果阿通过 "一个健康 "的综合方法消除了人类狂犬病。

156.Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy.

Cryo-EM结构确定了泛醌-10与线粒体复合体I的结合以及伴随Q位点占用的构象转换。

157.Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts.

通过调节癌症相关的成纤维细胞逆转光热疗法诱发的肿瘤复发和转移的不足。

158.Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD.

脑脊液中的聚（GR）和聚（GA）作为C9ORF72-ALS/FTD的潜在生物标志物。

159.SARS-CoV-2 transmission and impacts of unvaccinated-only screening in populations of mixed vaccination status.

SARS-CoV-2的传播以及在混合疫苗接种状态的人群中只进行未接种疫苗筛查的影响。

160.Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells.

目标受体的识别和随后用封装和工程异体干细胞治疗切除的脑肿瘤。

161.A deep learning model and human-machine fusion for prediction of EBV-associated gastric cancer from histopathology.

深度学习模型和人机融合，从组织病理学上预测EB病毒相关的胃癌。

162.The use of single-cell multi-omics in immuno-oncology.

单细胞多组学在免疫肿瘤学中的应用。

163.Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation.

链球菌Siglec样粘附物中糖类选择性的起源表明受体适应机制。

164.Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development.

突触支架蛋白Dlgap4在大脑皮层发育过程中脑室表面完整性和神经元迁移中的新作用。

165.Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits.

食物喜好的大规模GWAS揭示了遗传决定因素和与不同神经生理特征的遗传相关性。

166.Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates.

去泛素化酶和蛋白酶体调节泛素底物的优选集。

167.Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide.

利尿药布美他尼抑制阳离子-氯化物共转运体NKCC1的结构基础。

168.Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.

相变和重塑复合物的组装对滑膜肉瘤的SS18-SSX致癌活性很重要。

169.HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.

HDLBP通过多价相互作用结合ER靶向的mRNA，促进跨膜和分泌蛋白的蛋白质合成。

170.Autophagy regulation by RNA alternative splicing and implications in human diseases.

RNA替代剪接对自噬的调控及对人类疾病的影响。

171.The planarian wound epidermis gene equinox is required for blastema formation in regeneration.

胎生动物的伤口表皮基因equinox在再生过程中需要形成囊膜。

172.Tempo and drivers of plant diversification in the European mountain system.

欧洲山地系统中植物多样化的速度和驱动因素。

173.Visual barcodes for clonal-multiplexing of live microscopy-based assays.

基于活体显微镜检测的克隆复用的视觉条码。

174.Extended intergenic DNA contributes to neuron-specific expression of neighboring genes in the mammalian nervous system.

延伸的基因间DNA有助于哺乳动物神经系统中邻近基因的神经元特异性表达。

175.Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers.

儿科和年轻成人癌症的全基因组和转录组分析的可行性。

176.Global diversity dynamics in the fossil record are regionally heterogeneous.

化石记录中的全球多样性动态是区域性的异质性的。

177.Extensible and self-recoverable proteinaceous materials derived from scallop byssal thread.

源自扇贝贝壳线的可扩展和可自我恢复的蛋白材料。

178.IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice.

IL-1R-IRAKM-Slc25a1信号轴重新规划脂肪细胞的脂肪生成以促进饮食诱导的小鼠肥胖。

179.Co-infection with SARS-CoV-2 Omicron and Delta variants revealed by genomic surveillance.

基因组监测揭示SARS-CoV-2 Omicron和Delta变种的共同感染。

180.Mutational landscape of normal epithelial cells in Lynch Syndrome patients.

林奇综合征患者正常上皮细胞的突变景观。

181.A Middle Pleistocene Denisovan molar from the Annamite Chain of northern Laos.

老挝北部Annamite链的中更新世丹尼索瓦人臼齿。

182.Differential regulation of alternative promoters emerges from unified kinetics of enhancer-promoter interaction.

从增强子-促进子相互作用的统一动力学中出现的替代性启动子的不同调节。

183.N-type fast inactivation of a eukaryotic voltage-gated sodium channel.

真核细胞电压门控钠通道的N型快速失活。

184.Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila.

果蝇不对称细胞分裂过程中皮质环蛋白A控制纺锤体方向。

185.Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure.

智能无线治疗仪接触镜对眼内压的电感应和调节。

186.Nucleotide-amino acid π-stacking interactions initiate photo cross-linking in RNA-protein complexes.

核苷酸-氨基酸π型堆积相互作用启动了RNA-蛋白质复合物中的光交联。

187.Deep learning modeling m6A deposition reveals the importance of downstream cis-element sequences.

深度学习建模的m6A沉积揭示了下游顺式元素序列的重要性。

188.Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms.

增强剂调节3′端加工活性以控制替代3′UTR异构体的表达。

189.Mineralogical control on methylotrophic methanogenesis and implications for cryptic methane cycling in marine surface sediment.

矿物学对甲基化甲烷生成的控制以及对海洋表层沉积物中隐性甲烷循环的影响。

190.Targeted detection of cancer at the cellular level during biopsy by near-infrared confocal laser endomicroscopy.

近红外共聚焦激光内窥镜在活检过程中在细胞水平上对癌症的定向检测。

191.Human-ignited fires result in more extreme fire behavior and ecosystem impacts.

人类引发的火灾导致更极端的火灾行为和生态系统的影响。

192.Ranking threats to biodiversity and why it doesn’t matter.

对生物多样性的威胁进行排序，以及为什么它并不重要。

193.Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists.

蛋白激酶C C1结构域与二酰甘油和其他激动剂相互作用的结构解剖。

194.A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs.

一个保守的YAP/Notch/REST网络控制着肺部的神经内分泌细胞命运。

195.Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria.

氨基酸运输系统b0,+生物生成和胱氨酸尿症中Ca2+介导的异质体高阶组装。

196.Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses.

过度磷酸化的tau自组装成无定形聚合体，引起TLR4依赖性反应。

197.Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis.

线粒体保持自律性单碳循环以赋予生长无关的癌细胞迁移和转移。

198.Identification of a modulator of the actin cytoskeleton, mitochondria, nutrient metabolism and lifespan in yeast.

鉴定酵母中肌动蛋白细胞骨架、线粒体、营养代谢和寿命的调节剂。

199.PlasmidMaker is a versatile, automated, and high throughput end-to-end platform for plasmid construction.

PlasmidMaker是一个多功能、自动化、高通量的端到端质粒构建平台。

200.Cooperative regulation of PBI1 and MAPKs controls WRKY45 transcription factor in rice immunity.

PBI1和MAPKs的合作调控控制水稻免疫中的WRKY45转录因子。

201.Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells.

老年造血干细胞染色质可及性中的表观遗传特征。

202.POD1-SUN-CRT3 chaperone complex guards the ER sorting of LRR receptor kinases in Arabidopsis.

POD1-SUN-CRT3伴侣复合物守护着拟南芥中LRR受体激酶的ER排序。

203.A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.

控制核糖核酸还原酶NrdR依赖性转录的核糖核酸感应寡聚机制。

204.Polymer-coated carbon nanotube hybrids with functional peptides for gene delivery into plant mitochondria.

聚合物包覆的碳纳米管与功能肽的混合体用于基因传递到植物线粒体。

205.Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.

嘌呤核苷酸的耗竭通过刺激丝氨酸合成途径促使细胞迁移。

206.A mathematical perspective on edge-centric brain functional connectivity.

以边缘为中心的大脑功能连接的数学视角。

207.Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2,3-dioxygenase-blockade tumor immunotherapy.

基于金属有机框架的多功能纳米反应器用于饥饿/氧化改善吲哚胺2,3-二氧酶阻断的肿瘤免疫治疗。

208.An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease.

人工智能指导下的签名揭示了MIS-C和川崎病的共同宿主免疫反应。

209.Learnings from Thailand in building strong surveillance for malaria elimination.

从泰国吸取经验教训，为消除疟疾建立强有力的监控。

210.Tackling malaria transmission at a single cell level in an endemic setting in sub-Saharan Africa.

在撒哈拉以南非洲的流行环境中，在单细胞水平上解决疟疾传播问题。

211.Malaria in 2022: Increasing challenges, cautious optimism.

2022年的疟疾：越来越多的挑战，谨慎的乐观。

212.A broader perspective on the economics of malaria prevention and the potential impact of SARS-CoV-2.

从更广泛的角度来看疟疾预防的经济性和SARS-CoV-2的潜在影响。

213.Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways.

2002年人类癌症的蛋白质组学特征揭示了泛癌症分子亚型和相关途径。

214.Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ.

通过PPARδ重塑肿瘤免疫微环境快速加速KRAS突变型胰腺癌的发生。

215.Structural identification of vasodilator binding sites on the SUR2 subunit.

SUR2亚基上血管扩张剂结合点的结构鉴定。

216.Phase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3.

相分离和锌诱导转变调节自闭症相关的CTTNBP2和SHANK3的突触分布和关联。

217.Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS.

由肌球蛋白19产生的机械不稳定性有助于线粒体嵴结构和OXPHOS。

218.Nuclear oligo hashing improves differential analysis of single-cell RNA-seq.

核寡头散列改善了单细胞RNA-seq的差异化分析。

219.N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer.

N6-甲基腺苷调节的FGFR4减弱了顽固性HER2阳性乳腺癌的铁质细胞死亡。

220.Modulating gene regulation function by chemically controlled transcription factor clustering.

通过化学控制转录因子聚类来调节基因调控功能。

221.Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms.

细胞类型依赖和独立机制对进化保守的肌肉肌纤维基质的调节。

222.Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant.

用灭活疫苗进行异源免疫，然后用mRNA增效剂引起对SARS-CoV-2 Omicron变体的强免疫力。

223.MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets.

MYC通过破坏雄性激素受体靶点的转录暂停释放来驱动侵略性前列腺癌。

224.Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants.

四价马赛克HexaPro-bearing纳米颗粒疫苗可防止SARS-CoV-2变体的感染。

225.On the origins of conductive pulse sensing inside a nanopore.

论纳米孔内导电脉冲感应的起源。

226.Cryo-EM structure of human glucose transporter GLUT4.

人类葡萄糖转运体GLUT4的低温EM结构。

227.Testing the adaptive hypothesis of lagging-strand encoding in bacterial genomes.

测试细菌基因组中滞后链编码的适应性假说。

228.Variant calling from scRNA-seq data allows the assessment of cellular identity in patient-derived cell lines.

从scRNA-seq数据中调用变体，可以评估患者衍生的细胞系的细胞身份。

229.Reply to: Testing the adaptive hypothesis of lagging-strand encoding in bacterial genomes.

回复：测试细菌基因组中滞后链编码的适应性假说。

230.Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells.

Runx1和Runx2抑制了造血干细胞的细胞龛的纤维化转换。

231.In vitro reconstitution of Escherichia coli divisome activation.

大肠杆菌分裂体激活的体外重组。

232.Structural basis of ion – substrate coupling in the Na+-dependent dicarboxylate transporter VcINDY.

Na+依赖性二羧酸盐转运体VcINDY中离子-底物偶联的结构基础。

233.Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.

外源性抑制剂抑制人类葡萄糖转运体的分子基础。

234.Genomic diversity across the Rickettsia and ‘Candidatus Megaira’ genera and proposal of genus status for the Torix group.

Rickettsia和 "Candidatus Megaira "属的基因组多样性以及Torix组的属地位建议。

235.Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans.

Neuroligin介导的神经发育缺陷由线粒体功能障碍诱发，并由叶黄素在C. elegans中预防。

236.Large differences in carbohydrate degradation and transport potential among lichen fungal symbionts.

地衣真菌共生体之间碳水化合物降解和运输潜力的巨大差异。

237.Reconstruct high-resolution 3D genome structures for diverse cell-types using FLAMINGO.

利用FLAMINGO重建不同细胞类型的高分辨率三维基因组结构。

238.Active conformation of the p97-p47 unfoldase complex.

p97-p47解折叠酶复合物的活性构象。

239.Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins.

腔内压力的机械加载通过调节F-BAR蛋白的TOCA家族来介导伤口血管生成。

240.MRNIP condensates promote DNA double-strand break sensing and end resection.

MRNIP凝集物促进DNA双链断裂感应和末端切除。

241.Diurnal changes in the efficiency of information transmission at a sensory synapse.

感官突触处信息传输效率的昼夜变化。

242.Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice.

氯胺酮激活了成年出生的未成熟颗粒神经元，迅速缓解了小鼠的抑郁症样行为。

243.Benchmarking of analysis strategies for data-independent acquisition proteomics using a large-scale dataset comprising inter-patient heterogeneity.

利用包含患者间异质性的大规模数据集对数据无关的采集蛋白组学分析策略进行基准测试。

244.Characterization of RNA content in individual phase-separated coacervate microdroplets.

单个相分离的共析微滴中RNA含量的特征。

245.Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine.

缺少活性位点谷氨酰胺的光氧电压受体的信号转导。

246.Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex.

NALCN-FAM155A-UNC79-UNC80通道复合物的结构和机制。

247.Arabidopsis cryptochrome 2 forms photobodies with TCP22 under blue light and regulates the circadian clock.

拟南芥隐色体2在蓝光下与TCP22形成光体并调控昼夜节律。

248.Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins.

对糖基磷脂酰肌醇锚定蛋白的生物生成的分子见解。

249.Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis.

结核分枝杆菌核糖体结合的TAC毒素的底物识别和低温EM结构。

250.Dissociable multi-scale patterns of development in personalized brain networks.

个人化大脑网络中可分离的多尺度发展模式。

251.Sensory adaptation mediates efficient and unambiguous encoding of natural stimuli by vestibular thalamocortical pathways.

感觉适应介导前庭丘脑皮层通路对自然刺激进行有效和明确的编码。

252.Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes.

具有最小PAM CRISPR-Cas9酶的动物的基因组编辑。

253.Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia.

线粒体复合体I的种系突变揭示了IDH1突变的急性骨髓性白血病的遗传和靶向脆弱性。

254.Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury.

小鼠脑外伤后成人对侧皮质胼胝体神经元的选择性可塑性。

255.CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer.

CDK12促进肿瘤发生，但诱导乳腺癌对抑制叶酸一碳代谢的疗法的脆弱性。

256.Multimodal CEA-targeted fluorescence and radioguided cytoreductive surgery for peritoneal metastases of colorectal origin.

多模式CEA靶向荧光和放射引导下的结直肠腹膜转移的细胞修复手术。

257.Dual-resolving of positional and geometric isomers of C=C bonds via bifunctional photocycloaddition-photoisomerization reaction system.

通过双功能光合作用-光合作用异构化反应体系对C=C键的位置和几何异构体进行双重解析。

258.Deep learning of a bacterial and archaeal universal language of life enables transfer learning and illuminates microbial dark matter.

细菌和古生物通用生命语言的深度学习实现了转移学习并照亮了微生物暗物质。

259.Gasdermin-A3 pore formation propagates along variable pathways.

Gasdermin-A3孔隙的形成沿可变路径传播。

260.Unlocking the functional potential of polyploid yeasts.

释放多倍体酵母的功能潜力。

261.A rare variant analysis framework using public genotype summary counts to prioritize disease-predisposition genes.

使用公共基因型摘要计数的罕见变异体分析框架，以确定疾病倾向基因的优先次序。

262.Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation.

免疫分析揭示了与干细胞移植后巨细胞病毒反应轨迹相关的细胞亚群。

263.TMEM16 scramblases thin the membrane to enable lipid scrambling.

TMEM16扰动器使膜变薄，从而实现了脂质扰动。

264.3D chromatin remodelling in the germ line modulates genome evolutionary plasticity.

生殖线中的三维染色质重塑调节基因组的进化可塑性。

265.Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish.

社会隔离通过幼年斑马鱼的共同催产素回路调节食欲和回避行为。

266.PERSIST platform provides programmable RNA regulation using CRISPR endoRNases.

PERSIST平台利用CRISPR内切酶提供可编程的RNA调控。

267.Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine.

遗传分析确定了血液蛋白的多态性和因果关系，并强调Wnt/β-catenin信号在偏头痛中的作用。

268.Possible stochastic sex determination in Bursaphelenchus nematodes.

布尔逊线虫可能的随机性别决定。

269.Agrobacterium expressing a type III secretion system delivers Pseudomonas effectors into plant cells to enhance transformation.

表达III型分泌系统的农杆菌将假单胞菌效应物送入植物细胞以加强转化。

270.Metabolite trafficking enables membrane-impermeable-terpene secretion by yeast.

代谢物贩运使酵母的膜渗透性萜类物质分泌成为可能。

271.Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19.

现成的CAR自然杀伤细胞分泌IL-15靶向秒杀治疗COVID-19。

272.Translaminar recurrence from layer 5 suppresses superficial cortical layers.

来自第5层的平移复发抑制了浅层皮质层。

273.AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.

AIMP2-DX2为控制KRAS驱动的肿瘤发生提供治疗接口。

274.Discovery and characterization of a terpene biosynthetic pathway featuring a norbornene-forming Diels-Alderase.

以降冰片形成的Diels-Alderase为特征的萜类生物合成途径的发现和特征分析。

275.Activation of Xist by an evolutionarily conserved function of KDM5C demethylase.

KDM5C去甲基化酶的进化保守功能对Xist的激活。

276.Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits.

撒哈拉以南非洲研究的Meta分析提供了对脂质性状遗传结构的见解。

277.Thioesters provide a plausible prebiotic path to proto-peptides.

硫酸盐为原生肽提供了一个合理的前生物途径。

278.Activity-induced polar patterns of filaments gliding on a sphere.

在球体上滑行的丝状物的活动诱导极性模式。

279.Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients.

关于COVID-19门诊患者疗养血浆的两项随机试验的前瞻性个体患者数据元分析。

280.Systematic and quantitative view of the antiviral arsenal of prokaryotes.

原核生物的抗病毒武器库的系统和定量观点。

281.Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host.

累积的SARS-CoV-2突变和一个免疫力低下的病人免疫力的相应变化表明病毒在宿主体内的进化。

282.The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites.

G-蛋白偶联受体的口袋组揭示了以前未被瞄准的异生位点。

283.EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation.

EZH2通过整合素β1-FAK的激活参与TGFβ信号的传递，促进乳腺癌骨转移。

284.Environmental cues from neural crest derivatives act as metastatic triggers in an embryonic neuroblastoma model.

神经嵴衍生物的环境线索在胚胎神经母细胞瘤模型中充当转移的触发器。

285.Statin therapy inhibits fatty acid synthase via dynamic protein modifications.

他汀类药物治疗通过动态蛋白修饰抑制脂肪酸合成酶。

286.Profiling of hMPV F-specific antibodies isolated from human memory B cells.

从人类记忆B细胞中分离出的hMPV F特异性抗体的分析。

287.Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer.

长读测序揭示了高分辨率HPV整合及其在宫颈癌中的致癌进展。

288.A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells.

全基因组CRISPR-Cas9基因敲除筛选发现人类滋养细胞干细胞中的重要和限制生长的基因。

289.Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection.

作为SARS-CoV-2感染的有效抑制剂的多价9-O-乙酰化谷氨酸糖簇。

290.Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy.

怀孕期间接种COVID-19疫苗的有效性和围产期结果的系统回顾和荟萃分析。

291.A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease.

微生物组网络对非酒精性脂肪肝患者运动和饮食干预的反应的随机对照试验。

292.Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic.

来自欧洲的存档流感病毒基因组揭示了1918年大流行期间的基因组变异性。

293.Serum metabolome associated with severity of acute traumatic brain injury.

与急性创伤性脑损伤严重程度有关的血清代谢组。

294.Identification of oleoylethanolamide as an endogenous ligand for HIF-3α.

鉴定油酰乙醇酰胺为HIF-3α的内源性配体。

295.Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics.

血浆膜磷脂酰肌醇（4,5）-二磷酸对确定上皮特征至关重要。

296.Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.

ATP位点和异生型EGFR抑制剂合作结合和协同作用的分子基础。

297.Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches.

空间表征组学揭示了癌症干细胞微循环特有的A-I编辑组。

298.A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites.

一种负溶于水的荧光探针用于观察细胞内脂肪酸代谢物的分布。

299.Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles.

双击基因驱动使用迭代基因组靶向，帮助克服抗性等位基因。

300.The evolution of trait variance creates a tension between species diversity and functional diversity.

性状变异的进化造成了物种多样性和功能多样性之间的矛盾。

301.Modulating the evolutionary trajectory of tolerance using antibiotics with different metabolic dependencies.

利用具有不同代谢依赖性的抗生素调控耐受性的进化轨迹。

302.Targeting double-strand break indel byproducts with secondary guide RNAs improves Cas9 HDR-mediated genome editing efficiencies.

用二级导引RNA靶向双链断裂吲哚副产物提高Cas9 HDR介导的基因组编辑效率。

303.Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate.

肠道微生物群通过丁酸盐介导的肠道屏障功能的改变来调节急性骨髓性白血病。

304.Contribution of rare whole-genome sequencing variants to plasma protein levels and the missing heritability.

罕见全基因组测序变体对血浆蛋白水平的贡献及缺失的遗传性。

305.Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.

人类跨模式皮层结构和功能的遗传和系统发育解耦。

306.Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer.

Caveolin-1的时间调控增强了异质性胃癌的抗体药物疗效。

307.Culling corallivores improves short-term coral recovery under bleaching scenarios.

捕杀珊瑚动物可改善白化情况下的短期珊瑚恢复。

308.SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters.

SARS-CoV-2感染诱发金色叙利亚仓鼠的炎症性骨质流失。

309.Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP.

BiP催化的内质网中压力诱导的蛋白质分解。

310.Ataluren binds to multiple protein synthesis apparatus sites and competitively inhibits release factor-dependent termination.

Ataluren与多个蛋白质合成器位点结合并竞争性地抑制释放因子依赖的终止。

311.Distinctive molecular features of regenerative stem cells in the damaged male germline.

受损男性生殖系统中再生干细胞的独特分子特征。

312.Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure.

钙突发使上皮细胞伤口闭合过程中EFhD2/Swip-1交联的肌动蛋白网络快速重组。

313.SIMILE enables alignment of tandem mass spectra with statistical significance.

SIMILE使串联质谱的排列具有统计学意义。

314.An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis.

一种通过自体干细胞招募和血管生成实现颅骨再生的即时固定和自适应支架。

315.Neural signals regulating motor synchronization in the primate deep cerebellar nuclei.

调节灵长类小脑深部核团运动同步的神经信号。

316.Structure of the Arabidopsis guard cell anion channel SLAC1 suggests activation mechanism by phosphorylation.

拟南芥守护细胞阴离子通道SLAC1的结构表明磷酸化的激活机制。

317.Competition contributes to both warm and cool range edges.

竞争有助于暖区和冷区边缘的形成。

318.A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury.

损伤后生长板软骨再生需要FoxA2+长期干细胞群。

319.Preventing erosion of X-chromosome inactivation in human embryonic stem cells.

防止人类胚胎干细胞中X染色体失活的侵蚀。

320.Rationally engineering santalene synthase to readjust the component ratio of sandalwood oil.

合理设计檀香烯合成酶，重新调整檀香油的成分比例。

321.Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021.

2020-2021年加纳SARS-CoV-2感染的遗传多样性。

322.WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour.

在果蝇的雄性求偶行为中，WAKE通过层次分明的神经内分泌轴对cVA感知的调节。

323.Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1.

位于葡萄球体的电压依赖性氯离子通道VCCN1的低温电镜结构。

324.Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer.

调节IRE1α依赖性衰变（RIDD）介导的癌症中脂质代谢的重新编程。

325.Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions.

有丝分裂细胞分裂过程中含H3.3的核糖体的稳定继承。

326.Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury.

铂金纳米抗氧化剂和一氧化氮对肝脏缺血再灌注损伤的保护作用。

327.Regulation of A-to-I RNA editing and stop codon recoding to control selenoprotein expression during skeletal myogenesis.

调节A-I RNA编辑和终止密码子重编码以控制骨骼肌生成过程中硒蛋白的表达。

328.Dandelion pappus morphing is actuated by radially patterned material swelling.

蒲公英蛹的形态是由径向图案的材料膨胀驱动的。

329.Fibronectin binding protein B binds to loricrin and promotes corneocyte adhesion by Staphylococcus aureus.

纤连蛋白结合蛋白B与Loricrin结合，促进金黄色葡萄球菌的角质细胞粘附。

330.Transmembrane stem cell factor protein therapeutics enhance revascularization in ischemia without mast cell activation.

跨膜干细胞因子蛋白治疗剂在不激活肥大细胞的情况下增强缺血时的血管再通。

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