国际兽医癫痫工作组共识建议：欧洲犬癫痫的药物治疗

Sofie F.M. Bhatti1*, Luisa De Risio2 , Karen Muñana3 , Jacques Penderis4 , Veronika M. Stein5 , Andrea Tipold5 , Mette Berendt6 , Robyn G. Farquhar7 , Andrea Fischer8 , Sam Long9 , Wolfgang Löscher10, Paul J.J. Mandigers11, Kaspar Matiasek12, Akos Pakozdy13, Edward E. Patterson14, Simon Platt15, Michael Podell16, Heidrun Potschka17, Clare Rusbridge18,19 and Holger A. Volk20 

翻译 By @苏苏苏苏乔

校正 By @宠物神经科医生高健

Pet owner education
宠主教育

In order to promote a successful management of an epileptic pet, owners need to be educated thoroughly on[23, 32, 91]:

为了促进癫痫宠物病情控制的成功，需要对宠主进行彻底的教育[23,32,91]:

• The disease of their pet and the influence on their daily life (considerations regarding e.g. leaving the dog alone, what to do if travelling and leaving the dog in a kennel, fears of behavioural comorbidities, …)

• The need for AED therapy and the understanding that this often is a lifetime commitment

• The aim of AED therapy

• The importance of regular administration of AEDs

• The fact that dose adjustments should only be made after consulting a veterinarian – Potential adverse effects of AED therapy

• The importance of maintaining a detailed seizure diary

• The importance of regular check-ups to monitor AED blood concentrations as well as haematology/serum biochemistry where appropriate

• The need for treatment modulation to achieve optimal seizure control – The possibility of occurrence of status epilepticus and cluster seizures and the administration of additional AEDs at home

• Costs involved

• The fact that drug interactions might occur when combined with other AEDs or non-AEDs

• The understanding that abrupt drug withdrawal might be detrimental

• The fact that diet (e.g salt content), diarrhoea and vomiting may affect the absorption of AEDs. It should be advised to keep the diet constant or to make changes gradually and seek veterinary advice if gastrointestinal signs occur.

• 宠物的疾病及其对他们日常生活的影响（例如，考虑让犬独处，如果旅行和把犬留在犬舍时该怎么做，对行为学并发症的恐惧……）

• 对抗癫痫药物治疗的需求，并认识到这往往需要保证终身服药

• 抗癫痫药物治疗的目的

• 定期规律使用抗癫痫药物的重要性

• 只有在咨询兽医后才能调整剂量

• 抗癫痫药物治疗的潜在不良影响

• 记录详细的抽搐发作日志的重要性

• 定期复查以监测抗癫痫药物血液浓度以及血液学/血清生化的重要性

• 调整治疗方式以达到最佳的抽搐控制的需求

• 发生癫痫持续状态和丛集性抽搐发作的可能性，以及如何在家中使用额外的抗癫痫药物

• 所涉及的花费

• 药物与其他抗癫痫药物或非抗癫痫药物合用时可能发生相互作用的事实

• 认识到突然停药可能是致命性的

• 饮食（例如含盐量）、腹泻和呕吐可能影响抗癫痫药物的吸收。 应建议保持饮食不变或逐渐改变，如果出现胃肠道症状，应寻求兽医的建议。