【标题速读】【Ncomm】【biological-sciences】【2022年】【4月】
声明：本专栏主要对生命科学领域的一些期刊文章标题进行翻译，所有内容均由本人手工整理翻译。由于本人专业为生物分析相关，其他领域如果出现翻译错误请谅解。
1.Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.
组蛋白伴侣CAF-1对染色质可及性的调控维持了血统的忠实性。
2.Molecular basis of antibiotic self-resistance in a bee larvae pathogen.
蜜蜂幼虫病原体的抗生素自我抵抗的分子基础。
3.Knowledge integration and decision support for accelerated discovery of antibiotic resistance genes.
加速发现抗生素耐药基因的知识整合和决策支持。
4.Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer.
对1015名患者外显子组的综合分析揭示了结直肠癌的基因组-临床关联。
5.Mechanism of integrin activation by talin and its cooperation with kindlin.
Talin激活整合素的机制及其与kindlin的合作。
6.CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway.
具有无义密码子的CFTR mRNA被SMG6介导的核酸内切降解途径所降解。
7.Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis.
Mitofusin 1和2对线粒体DNA含量的调节是决定葡萄糖平衡的一个关键因素。
8.In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
在晶体中观察到三种金属离子促进了 DNA 聚合酶的错误掺入。
9.Reference-free cell type deconvolution of multi-cellular pixel-resolution spatially resolved transcriptomics data.
多细胞像素空间分辨率转录组学数据的无参考细胞类型去卷积。
10.Radical SAM-dependent ether crosslink in daropeptide biosynthesis.
达罗肽生物合成中依赖SAM的自由基醚交联。
11.Trends and associated factors for Covid-19 hospitalisation and fatality risk in 2.3 million adults in England.
英国230万成年人Covid-19住院和死亡风险的趋势和相关因素。
12.Periodic formation of epithelial somites from human pluripotent stem cells.
来自人类多能干细胞的上皮体细胞的周期性形成。
13.Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma.
低氧激活的神经肽Y/Y5受体/RhoA途径引发尤文肉瘤的染色体不稳定和骨转移。
14.A reversibly gated protein-transporting membrane channel made of DNA.
一个由DNA组成的可逆门控的蛋白质运输膜通道。
15.Deficiency in coatomer complex I causes aberrant activation of STING signalling.
衣壳复合物I的缺陷导致STING信号的反常激活。
16.Synthetic cells with self-activating optogenetic proteins communicate with natural cells.
具有自激活光遗传蛋白的合成细胞与天然细胞沟通。
17.ERK1/2 is an ancestral organising signal in spiral cleavage.
ERK1/2是螺旋裂解的祖先组织信号。
18.Evolution of the murine gut resistome following broad-spectrum antibiotic treatment.
广谱抗生素治疗后小鼠肠道抗性组的进化。
19.Metabolic preference assay for rapid diagnosis of bloodstream infections.
用于快速诊断血流感染的代谢偏好测定。
20.Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression.
巴雷特食道癌前病变的体细胞全基因组动力学揭示了与疾病进展相关的特征。
21.A deep siamese neural network improves metagenome-assembled genomes in microbiome datasets across different environments.
深度连体神经网络改善了不同环境中微生物组数据集的元基因组。
22.An energizing role for motivation in information-seeking during the early phase of the COVID-19 pandemic.
在COVID-19大流行病的早期阶段，动机在信息搜索中发挥着活力。
23.TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance.
TGS1介导人类端粒酶RNA的2,2,7-三甲基鸟苷盖帽，以指导端粒酶依赖性端粒维护。
24.Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes.
血糖控制与2型糖尿病疫苗患者的SARS-CoV-2突破性感染有关。
25.Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth.
电化镁细胞产生氢气并调节肿瘤微环境以抑制癌症生长。
MgG是通过在Mg棒表面装饰铂而开发的，由于原电池加速水蚀刻Mg，它允许在水环境中连续产生H2。 通过将 MgG 棒植入肿瘤，可以在肿瘤内产生 H2 分子，从而诱导线粒体功能障碍和细胞内氧化还原稳态破坏。 同时，Mg(OH)2 残基可以中和酸性肿瘤微环境 (TME)。 这种具有微原电池结构的MgG棒使氢疗法能够抑制肿瘤的生长。
26.Kidney epithelial cells are active mechano-biological fluid pumps.
肾脏上皮细胞是活跃的机械-生物流体泵。
27.Structural insights into TRPV2 activation by small molecules.
对小分子激活TRPV2的结构性见解。
28.Kronos scRT: a uniform framework for single-cell replication timing analysis.
Kronos scRT：一个用于单细胞复制时间分析的统一框架。
29.Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia.
异体TCRαβ缺陷的CAR T细胞靶向CD123在急性骨髓性白血病中的应用.
30.Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage.
小鼠前脑背侧和腹侧少突胶质细胞祖细胞对DNA损伤反应的分子和功能异质性。
31.Evanescent scattering imaging of single protein binding kinetics and DNA conformation changes.
单一蛋白结合动力学和DNA构象变化的Evanescent 散射成像。
32.Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands.
Teneurins组装成突触前纳米团，通过突触后非Teneurins配体促进突触形成。
33.Crystal structures and insights into precursor tRNA 5’-end processing by prokaryotic minimal protein-only RNase P.
原核生物最小蛋白RNase P的晶体结构和对前体tRNA 5'端处理的见解。
34.A theory of cortical map formation in the visual brain.
视觉大脑中皮质地图形成的理论。
35.Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells.
使用异体抗CD123的CAR T细胞靶向母细胞性浆细胞样树突状细胞肿瘤的CD123。
36.Accuracy prompts are a replicable and generalizable approach for reducing the spread of misinformation.
准确性提示是减少错误信息传播的一种可复制和可推广的方法。
37.Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy.
HNRNPA2B1的杂合框架变异导致早发的眼咽肌肉萎缩症。
38.A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in ulcerative colitis.
用系统基因组学方法揭示溃疡性结肠炎患者的特定致病途径和蛋白质。
39.Enhancement of anaerobic glycolysis – a role of PGC-1α4 in resistance exercise.
无氧糖酵解的增强--PGC-1α4在阻力运动中的作用。
40.Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients.
肽聚糖的生物合成是由沿酶-底物亲和梯度的脂质转移驱动的。
41.Three-dimensional structure determination of protein complexes using matrix-landing mass spectrometry.
利用矩阵着陆质谱法确定蛋白质复合物的三维结构。
42.Leveraging omic features with F3UTER enables identification of unannotated 3’UTRs for synaptic genes.
利用F3UTER的omic特征，能够识别突触基因的未命名3'UTR。
43.The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins.
分化的时间和CD8效应功能的有效性是由RNA结合蛋白设定的。
44.Mutational meltdown of putative microbial altruists in Streptomyces coelicolor colonies.
Coelicolor链霉菌菌落中推测的微生物利他者的突变融化。
45.A cryptic pocket in Ebola VP35 allosterically controls RNA binding.
埃博拉病毒VP35中的一个隐性口袋异生控制了RNA的结合。
46.A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2.
人类血管活性肠多肽受体2的独特配体识别机制。
47.ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer.
ASCL1通过重塑前列腺癌的染色质图谱激活神经元干细胞样谱系编程。
48.L-tyrosine-bound ThiH structure reveals C–C bond break differences within radical SAM aromatic amino acid lyases.
L-酪氨酸结合的ThiH结构揭示了自由基SAM芳香族氨基酸裂解酶内部的C-C键断裂差异。
49.Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly.
折叠体揭示并验证了与毒性α-突触蛋白自组装有关的治疗目标。
50.EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma.
EWSR1-ATF1依赖性三维连接调控透明细胞肉瘤的致癌和分化程序。
51.Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease.
SARS-CoV-2主要蛋白酶的共价narlaprevir和boceprevir衍生的混合抑制剂。
52.Safety and serum distribution of anti-SARS-CoV-2 monoclonal antibody MAD0004J08 after intramuscular injection.
肌肉注射后抗SARS-CoV-2单克隆抗体MAD0004J08的安全性和血清分布。
53.The initial charge separation step in oxygenic photosynthesis.
含氧光合作用中的初始电荷分离步骤。
54.T follicular helper and B cell crosstalk in tertiary lymphoid structures and cancer immunotherapy.
T滤泡辅助细胞和B细胞在三级淋巴结构和癌症免疫治疗中的串扰。
55.Engineering artificial photosynthetic life-forms through endosymbiosis.
通过内共生来设计人工光合作用的生命形式。
56.A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis.
结核分枝杆菌的苷脂分泌和毒力需要一种周身收缩的蛋白。
57.T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling.
T细胞受体和IL-2信号强度通过染色质重塑控制记忆型CD8+T细胞的功能适应性。
58.Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys.
通过颅内宽视场光学成像揭示狨猴皮质功能的中观景观。
59.Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes.
用于心肌细胞平行和强大的细胞内记录的纳米冠电极。
60.Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.
Cul3-KLHL20 E3泛素连接酶在HIV-1 Nef和宿主SERINC5限制的军备竞赛中发挥关键作用。
61.Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association.
埃博拉病毒VP35通过与AKIP1联合，劫持了PKA-CREB1通路进行复制和致病。
62.Bloom helicase mediates formation of large single–stranded DNA loops during DNA end processing.
Bloom螺旋酶在DNA末端处理过程中介导了大型单链DNA环的形成。
63.Knockdown of GABAA alpha3 subunits on thalamic reticular neurons enhances deep sleep in mice.
丘脑网状神经元上GABAAα3亚基的敲除能增强小鼠的深度睡眠。
64.An osmium-peroxo complex for photoactive therapy of hypoxic tumors.
一种用于缺氧肿瘤光疗的锇-过氧化物复合物。
65.Spontaneous chiral symmetry breaking in a random driven chemical system.
随机驱动化学系统中自发的手性对称性破坏。
66.Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities.
机器学习耦合的组合诱变使CRISPR-Cas9基因组编辑活动的资源效率工程。
67.Deletion and tandem duplications of biosynthetic genes drive the diversity of triterpenoids in Aralia elata.
生物合成基因的删除和串联复制驱动了Aralia elata的三萜类化合物的多样性。
68.A dirigent family protein confers variation of Casparian strip thickness and salt tolerance in maize.
一个dirigent家族蛋白赋予了玉米的Casparian条带厚度和耐盐性的变化。
69.Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney.
转录因子AP-2α和AP-2β调节哺乳动物肾脏远端肾小管的不同部分。
70.Ratiometric afterglow luminescent nanoplatform enables reliable quantification and molecular imaging.
比率余辉发光纳米平台实现了可靠的量化和分子成像。
71.Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma.
负重活动通过YAP的激活损害了跖骨黑色素瘤的核膜和基因组完整性。
72.A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop.
蛋白质酪氨酸磷酸酶WPD环内非经典分子反应性的结构揭露。
73.Structure of ATP synthase under strain during catalysis.
催化过程中ATP合成酶受力的结构。
74.Reduced chromatin accessibility correlates with resistance to Notch activation.
染色质可及性的降低与对Notch激活的抵抗有关。
75.Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival.
胶质母细胞瘤干细胞的细胞系控制的表观遗传调控决定了功能不同的亚群，并预测了患者的生存。
76.Shared and unique brain network features predict cognitive, personality, and mental health scores in the ABCD study.
共享和独特的大脑网络特征预测ABCD研究中的认知、个性和心理健康分数。
77.Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2.
全基因组CRISPR筛选发现GATA6通过调节ACE2成为SARS-CoV-2的前病毒宿主因子。
78.A fungal extracellular effector inactivates plant polygalacturonase-inhibiting protein.
一种真菌的胞外效应物使植物多聚半乳糖醛酸酶抑制蛋白失活。
79.Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia.
丘脑下部核团通过减少猴子基底神经节的神经尖峰变异性来稳定运动。
80.Machine learning-based global maps of ecological variables and the challenge of assessing them.
基于机器学习的生态变量全球地图及评估挑战
81.Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia.
人类神经元的染色质分析揭示了组蛋白乙酰化和BET家族蛋白在精神分裂症中的反常作用。
82.Enabling reactive microscopy with MicroMator.
用MicroMator实现反应性显微镜的研究。
83.Comparing COVID-19-related hospitalization rates among individuals with infection-induced and vaccine-induced immunity in Israel.
比较以色列具有感染诱导和疫苗诱导免疫力的个体中与COVID-19相关的住院率。
84.Genetic analysis of over half a million people characterises C-reactive protein loci.
对50多万人的遗传分析表明了C反应蛋白位点的特点。
85.Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation.
致病的BRCA1变体破坏了PLK1对有丝分裂纺锤体定向的调节。
86.Mechanism of sensitivity modulation in the calcium-sensing receptor via electrostatic tuning.
钙感应受体中通过静电调谐的灵敏度调节机制。
87.A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.
可靶向的CoQ-FSP1轴驱动KEAP1不活跃的肺癌的铁中毒和抗辐射性。
88.CinA mediates multidrug tolerance in Mycobacterium tuberculosis.
CinA介导了结核分枝杆菌的多药耐受。
89.Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy.
TAK1的超生理激活促进骨骼肌生长并减轻神经源性萎缩。
90.ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage.
ZNF117调控胶质母细胞瘤干细胞向少突胶质细胞系分化。
91.Generic self-stabilization mechanism for biomolecular adhesions under load.
负载下的生物分子粘附的通用自稳定机制。
92.Bottlenecks and opportunities for synthetic biology biosafety standards.
合成生物学生物安全标准的瓶颈和机遇。
93.Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer.
单细胞转录组学发现Mcl-1是癌症中衰老治疗的目标。
94.PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration.
PD-L1信号传导选择性地调节T细胞淋巴跨内皮迁移.
95.Redesigning regulatory components of quorum-sensing system for diverse metabolic control.
重新设计法定人数感应系统的调节组件以实现多样化的代谢控制。
96.KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling.
KMT5A甲基化的SNIP1通过激活YAP信号传导促进三阴性乳腺癌的转移。
97.Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization.
通过大规模基因组重组出现的新型头足类基因调控和表达。
98.Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity.
人类胰腺癌器官的综合分析揭示了与药物敏感性相关的染色质可及性特征。
99.Snf7 spirals sense and alter membrane curvature.
Snf7螺旋体感知并改变膜曲率。
100.Niche expansion and adaptive divergence in the global radiation of crows and ravens.
乌鸦和乌鸦的全球辐射中的利基扩展和适应性分化。
101.Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy.
用于有效癌症光动力治疗的高尔基体靶向聚集诱导发射发光体。
102.App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden.
基于应用程序的COVID-19综合症监测和预测瑞典COVID症状研究中的入院情况。
103.USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma.
USP22通过稳定肝细胞癌的PPARγ来调节脂质体的积累。
104.AI-enabled, implantable, multichannel wireless telemetry for photodynamic therapy.
用于光动力疗法的AI-enabled、植入式、多通道无线遥测技术。
105.CMYA5 establishes cardiac dyad architecture and positioning.
CMYA5建立了心脏dyad架构和定位。
106.Metabolic plasticity can amplify ecosystem responses to global warming.
代谢的可塑性可以放大生态系统对全球变暖的反应。
107.TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer.
TRMT6/61A依赖的tRNA衍生片段的碱基甲基化调节膀胱癌的基因沉默活性和未折叠蛋白反应。
108.RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity.
CD8+T细胞中的RNA聚合酶II暂停因子NELF促进抗肿瘤免疫力。
109.Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions.
在不平等的细胞分裂过程中，Vasa核沿有丝分裂纺锤体进行不对称的翻译。
110.Tension can directly suppress Aurora B kinase-triggered release of kinetochore-microtubule attachments.
张力可直接抑制Aurora B激酶触发的激振子-微管附着物的释放。
111.High-throughput production of functional prototissues capable of producing NO for vasodilation.
高通量生产能够产生NO用于血管扩张的功能性原型组织。
112.Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration.
通过增强CCL2介导的CAR-T细胞迁移来锁定非小细胞肺癌的脑部病灶。
113.Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium.
单细胞转录组分析揭示了小鼠食道上皮细胞的多样性。
114.Lateral gain is impaired in macular degeneration and can be targeted to restore vision in mice.
侧面增益在黄斑变性中受损，可作为小鼠恢复视力的目标。
115.Genomic and metabolic adaptations of biofilms to ecological windows of opportunity in glacier-fed streams.
生物膜对冰川流的生态机会窗口的基因组和代谢适应。
116.Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
抗疟药泛酸MMV693183的临床前特征和目标验证。
117.Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model.
抑制硬脂酰-CoA去饱和酶可逆转阿尔茨海默病小鼠模型的免疫、突触和认知损伤。
118.Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model.
巨噬细胞亚型对人类多能干细胞衍生模型中SARS-CoV-2感染的不同影响。
119.A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways.
识别细胞粘附调节蛋白和信号通路的失粘性CRISPR-Cas9筛选平台。
120.Spontaneous variability in gamma dynamics described by a damped harmonic oscillator driven by noise.
由噪声驱动的阻尼谐波振荡器所描述的伽马动力学的自发变化。
121.Normalizing and denoising protein expression data from droplet-based single cell profiling.
对基于液滴的单细胞分析的蛋白质表达数据进行标准化和去噪处理。
122.Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells.
全球泛素组分析确定NEDD4是神经嵴细胞中Profilin 1和肌动蛋白重塑的调节器。
123.Human serum triggers antibiotic tolerance in Staphylococcus aureus.
人类血清引发了金黄色葡萄球菌的抗生素耐受性。
124.Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.
开发NanoLuc靶向蛋白降解剂和通用报告系统，以确定标签靶向降解平台的基准。
125.USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer.
USP25促进病理性HIF-1驱动的代谢重编程，是胰腺癌的潜在治疗目标。
126.Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population.
单细胞分析确定了一个高度再生和同质的人类CD34+造血干细胞群。
127.Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation.
替代剪接、NMD和蛋白质稳定性的多层次调节控制了TRIM46在轴突形成过程中的时间诱导和组织特异性表达。
128.Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo.
局部和底物特异性的S-棕榈酰化决定了Gαo的亚细胞定位。
129.A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance.
生物分子比例-积分-衍生反馈控制器的层次结构，用于强大的完美适应和动态性能。
130.Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.
对异源性与ATP竞争性AKT抑制剂产生不同的抗性机制。
131.High-quality genome and methylomes illustrate features underlying evolutionary success of oaks.
高质量的基因组和甲基组说明了橡树进化成功的基本特征。
132.Cooperative interaction between ERα and the EMT-inducer ZEB1 reprograms breast cancer cells for bone metastasis.
ERα和EMT诱导剂ZEB1之间的合作互动为乳腺癌细胞的骨转移重新编程。
133.An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA.
一种抗甲型流感病毒的微生物代谢物通过降解病毒内切酶PA发挥作用。
134.Genomic distances reveal relationships of wild and cultivated beets.
基因组距离揭示野生和栽培甜菜的关系。
135.TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease.
TNF是抑制自身免疫性疾病中前列腺炎症和增生的潜在治疗目标。
136.Accelerated biological aging in COVID-19 patients.
COVID-19患者的生物衰老加速。
137.Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism.
冠状动脉平滑肌中的吡啶核苷酸氧化还原电位将心肌血流与心脏代谢联系起来。
138.Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes.
星形细胞瘤表现出放射状胶质干细胞谱系以及印记和X-失活逃逸基因的不同表达。
139.ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation.
ESR1突变的乳腺癌显示出基底细胞角蛋白的升高和免疫激活。
140.The neural coding framework for learning generative models.
学习生成模型的神经编码框架。
141.Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment.
通常被认为与任务无关的信息驱动决策并影响运动前电路的招募。
142.Low complexity RGG-motif sequence is required for Processing body (P-body) disassembly.
处理体（P-body）的分解需要低复杂度的RGG-motif序列。
143.Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function.
肠道纤维网状细胞龛控制先天淋巴细胞的平衡和功能。
144.Bipartite network models to design combination therapies in acute myeloid leukaemia.
设计急性骨髓性白血病联合疗法的双元网络模型。
145.Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments reveals isoform-specific conformation and binding mode.
装配在肌动蛋白丝上的人类cofilin-2的魔角旋转核磁共振结构揭示了同种形式的特定构象和结合模式。
146.AKT mutant allele-specific activation dictates pharmacologic sensitivities.
AKT突变体等位基因的激活决定了药理学的敏感性。
147.Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.
血管内皮缺口信号的丧失促进三级淋巴结构的自发形成。
148.Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function.
Cavβ1独立于电压门控Ca2+通道功能调节T细胞扩张和凋亡。
149.A proteogenomic analysis of clear cell renal cell carcinoma in a C population.
C人群中透明细胞肾细胞癌的蛋白质基因组学分析。
150.Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
肽的选择性和人类神经素U受体的激活的结构性见解。
151.Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts.
小细胞肺癌患者衍生的异种移植库的基因组和转录组分析。
152.A natural allele of OsMS1 responds to temperature changes and confers thermosensitive genic male sterility.
OsMS1的一个天然等位基因对温度变化有反应，并赋予热敏基因雄性不育。
153.Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability.
抑制急性骨髓性白血病中的琥珀酰脱氢酶复合物导致乳酸盐驱动的呼吸道代谢脆弱。
154.DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion.
DENR控制JAK2翻译，诱导PD-L1表达，用于肿瘤免疫逃避。
155.Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription.
ID2与无性繁殖复合物的调节性相互作用将有丝分裂的进展与细胞类型特异性转录的重新激活联系起来。
156.Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle.
卡路里限制和雷帕霉素在老化骨骼肌中的独特和相加效应。
157.Boron encapsulated in a liposome can be used for combinational neutron capture therapy.
包裹在脂质体中的硼可用于组合式中子捕获疗法。
158.CO2 signaling mediates neurovascular coupling in the cerebral cortex.
CO2信号介导大脑皮层的神经血管偶联。
159.Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations.
化疗诱导的癌细胞COX-2上调确定了其炎症特性，并限制了化疗免疫疗法组合的疗效。
160.A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation.
一种白血病保护性种系变体通过转录因子成核介导染色质模块形成。
161.Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF.
对亚千碱基染色质拓扑结构的分析揭示了纳米级的调控相互作用，对聚合酶和CTCF的依赖程度不同。
162.Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes.
靶向TCTP通过逆转免疫难治的表型使肿瘤对T细胞介导的治疗敏感。
163.Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models.
转移性小细胞肺癌和患者衍生模型中神经内分泌转录状态的异质性。
164.Bird populations most exposed to climate change are less sensitive to climatic variation.
最受气候变化影响的鸟类种群对气候变异的敏感性较低。
165.Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis.
胰岛素的作用和抵抗依赖于GSK3β-FBXW7-ERRα的转录轴。
166.Microridge-like structures anchor motile cilia.
微脊状结构固定了运动的纤毛。
167.Honeybee gut Lactobacillus modulates host learning and memory behaviors via regulating tryptophan metabolism.
蜜蜂肠道乳酸菌通过调节色氨酸代谢调节宿主学习和记忆行为。
168.Structure, gating, and pharmacology of human CAV3.3 channel.
人类CAV3.3通道的结构、门控和药理学。
169.A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation.
POLD3/BLM依赖性途径处理RNA：DNA杂交积累过多时转录染色质中的DSBs。
170.An evolutionarily conserved stop codon enrichment at the 5′ ends of mammalian piRNAs.
哺乳动物piRNA的5′端有一个进化保守的终止密码子富集。
171.Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice.
肠道微生物群-胆汁酸串联有助于小鼠热量限制后体重的反弹性增加。
172.Secondary structure RNA elements control the cleavage activity of DICER.
二级结构RNA元素控制DICER的裂解活性。
173.Connecting high-resolution 3D chromatin organization with epigenomics.
高分辨率三维染色质组织与表观基因组学的联系。
174.Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery.
生物正交原位组装的纳米药物作为细胞外给药的药物库。
175.An analysis of neuroscience and psychiatry papers published from 2009 and 2019 outlines opportunities for increasing discovery of sex differences.
对2009年至2019年发表的神经科学和精神病学论文的分析，概述了增加发现性别差异的机会。
176.A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea.
用于增强改善抗生素相关腹泻的益生菌的单细胞纳米涂层。
a 纳米装甲可实现快速且高度生物相容的单细胞封装，从而保护其免受具有不同分子结构和特性的多种抗生素的侵害。 b 可以将装甲益生菌冷冻干燥并装入设计用于口服给药的肠溶胶囊中。 c 肠溶胶囊在胃运输的低 pH 值期间保持完整，并在肠道中释放装甲益生菌。 d 抗生素较差的特异性通常会耗尽肠道中的健康共生菌并阻碍益生菌治疗。 e nanoarmor 为抗生素中的有益细菌提供安全和短暂的涂层，促进健康的微生物繁殖。
177.Generation of human islet cell type-specific identity genesets.
人类胰岛细胞类型特异性身份基因组的产生。
178.Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling.
内皮祖细胞通过FOXF1介导的BMP9/ACVRL1信号的激活刺激新生儿肺部血管生成。
179.Communication-efficient federated learning via knowledge distillation.
通过知识提炼实现沟通效率的联合学习。
180.Local structure-function relationships in human brain networks across the lifespan.
人类大脑网络在整个生命周期中的局部结构-功能关系。
181.Membrane marker selection for segmenting single cell spatial proteomics data.
用于分割单细胞空间蛋白质组学数据的膜标志物选择。
182.Chromosome evolution and the genetic basis of agronomically important traits in greater yam.
大山药的染色体进化和重要农艺性状的遗传基础。
183.Hidden information on protein function in censuses of proteome foldedness.
蛋白质组折叠度普查中隐藏的蛋白质功能信息。
184.Interactive single-cell data analysis using Cellar.
使用Cellar的交互式单细胞数据分析.
185.A pair of non-Mendelian genes at the Ga2 locus confer unilateral cross-incompatibility in maize.
玉米Ga2基因座上的一对非孟德尔基因赋予玉米单侧交叉相容性。
186.Light triggered nanoscale biolistics for efficient intracellular delivery of functional macromolecules in mammalian cells.
哺乳动物细胞中功能性大分子的高效细胞内传递的光触发纳米生物技术。
187.Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae.
发芽过程中适应蛋白Mmr1的蛋白分解对酿酒酵母的线粒体稳态是必要的。
188.Differences in RNA polymerase II complexes and their interactions with surrounding chromatin on human and cytomegalovirus genomes.
人类和巨细胞病毒基因组上的RNA聚合酶II复合体及其与周围染色质的相互作用的差异。
189.CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model.
CDP-核糖醇原药治疗改善ISPD缺陷型肌肉萎缩症小鼠模型。
190.Microvascular stabilization via blood-brain barrier regulation prevents seizure activity.
通过血脑屏障调节微血管稳定可防止癫痫活动。
191.Adaptive responses of marine diatoms to zinc scarcity and ecological implications.
海洋硅藻对锌匮乏的适应性反应及生态学意义。
192.The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.
核受体ERR与致心因子GATA4合作，协调心肌细胞的成熟。
193.Data-driven learning how oncogenic gene expression locally alters heterocellular networks.
数据驱动的学习：致癌基因表达如何局部改变异质细胞网络。
194.Genomic evidence for homoploid hybrid speciation between ancestors of two different genera.
两个不同属的祖先之间的同倍体杂交物种的基因组证据。
195.Structural basis for the assembly and quinone transport mechanisms of the dimeric photosynthetic RC–LH1 supercomplex.
二聚体光合作用RC-LH1超级复合体的组装和醌运输机制的结构基础。
196.PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity.
PD-L1和ICOSL在癌症、过敏和自身免疫中对人类分泌型和帮助型树突状细胞的鉴别。
197.Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine.
青少年BNT162b2强化后的保护作用大大超过新鲜2剂疫苗的保护作用。
198.Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα.
Presenilin 2 N141I突变通过表观遗传学抑制REV-ERBα诱发高活性免疫反应。
199.Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer.
p85β的核转位促进PIK3CA螺旋结构域突变癌的肿瘤发生。
200.Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer.
交感神经轴突萌发诱导巨噬细胞种群变化并保护胰腺癌。
201.CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling.
CHD7通过抑制PPAR-γ信号调节骨脂肪平衡。
202.Using deep learning to predict abdominal age from liver and pancreas magnetic resonance images.
使用深度学习从肝脏和胰腺磁共振图像预测腹部年龄。
203.Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions.
非药物COVID-19干预措施对呼吸系统疾病临床试验的干扰建模。
204.Anopheles mosquitoes reveal new principles of 3D genome organization in insects.
按蚊揭示了昆虫三维基因组组织的新原则。
205.Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling.
人类胰腺微环境通过非经典的WNT5A/JNK和BMP信号促进β细胞分化。
206.Inducible and reversible RNA N6-methyladenosine editing.
诱导性和可逆性RNA N6-甲基腺苷编辑。
207.Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window.
通过光学清除的椎间孔窗对小鼠脊髓进行长期的体内成像。
208.ComFC mediates transport and handling of single-stranded DNA during natural transformation.
ComFC介导了自然转化过程中单链DNA的运输和处理。
209.Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila.
群体规模的长读测序发现了与果蝇基因表达变化和适应性特征相关的可转座元素。
210.A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity.
具有亚克隆敏感性的机器学习算法揭示了广泛的泛癌症人类白细胞抗原杂合度的丧失。
211.The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor.
iC3b-CR3 αI的晶体结构揭示了CR3整合素受体对主要造血干细胞iC3b的模块化识别。
212.Persistent COVID-19 symptoms in a community study of 606,434 people in England.
英国一项对606,434人的社区研究中的持续COVID-19症状。
213.Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.
小胶质细胞NF-κB驱动tauopathy小鼠模型中tau的扩散和毒性。
214.Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy.
用于癌症治疗的免疫检查点抑制剂诱发的炎症性关节炎的独特分子和免疫特征。
215.Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events.
使用高分辨率接触网络评估SARS-CoV-2在大规模多日活动中的传播和控制。
216.SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes.
SWI/SNF和组蛋白伴侣Rtt106驱动多种抗药性网络基因的表达。
217.Deforestation-induced climate change reduces carbon storage in remaining tropical forests.
毁林引起的气候变化减少了剩余热带森林的碳储存。
218.Trade-off between tree planting and wetland conservation in China.
中国植树和湿地保护之间的权衡。
219.Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers.
斑马鱼胰腺的多维染色质谱分析，发现并研究与疾病相关的增强子。
220.Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.
泛素样蛋白 3 (UBL3) 是主要组织相容性复合体 II 类和 CD86 的 MARCH 泛素化所必需的。
221.Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24.
对多功能抗CRISPR蛋白AcrIF24抑制I-F型CRISPR-Cas系统的深入研究。
222.Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers.
暂时性病毒暴露驱动HIV-1治疗后控制者的功能协调的体液免疫反应。
223.Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.
单细胞RNA测序与大颗粒淋巴细胞白血病T细胞的TCR分析相结合。
224.Impact of horizontal gene transfer on emergence and stability of cooperative virulence in Salmonella Typhimurium.
水平基因转移对鼠疫沙门氏菌合作毒力的出现和稳定性的影响。
225.Reprogrammed tracrRNAs enable repurposing of RNAs as crRNAs and sequence-specific RNA biosensors.
重新编程的tracrRNAs使RNA被重新利用为crRNAs和序列特定的RNA生物传感器。
226.Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia.
CD8+T细胞大颗粒淋巴细胞白血病中白血病和非白血病免疫复合物的单细胞特征。
227.Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma.
PD-L1阻断后外周血中的新抗原特异性CD8 T细胞反应可能预测转移性尿路上皮癌的治疗结果。
228.Designing highly multiplex PCR primer sets with Simulated Annealing Design using Dimer Likelihood Estimation (SADDLE).
使用二聚体似然估计(SADDLE) 通过模拟退火设计设计高度多重 PCR 引物组。
229.Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors.
Mn (II)的碳化顺磁性复合物作为造影剂用于亚毫米级正位肿瘤的精确磁共振成像。
230.Electrocorticographic evidence of a common neurocognitive sequence for mentalizing about the self and others.
皮质电图证明了对自我和他人进行心理暗示的共同神经认知序列。
231.Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip.
在人类肺泡芯片中发现的针对病毒感染的先天免疫反应的机械控制。
232.Congruent evolutionary responses of European steppe biota to late Quaternary climate change.
欧洲草原生物群对第四纪晚期气候变化的一致的进化反应。
233.Learning meaningful representations of protein sequences.
学习有意义的蛋白质序列表征.
234.Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR.
通过MAS NMR揭示灵活环路对0.5 MDa TET氨基肽酶的功能控制。
235.Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling.
泛素连接酶STUB1破坏IFNγ受体复合物的稳定性以抑制肿瘤IFNγ信号传导。
236.Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage.
全球SARS-CoV-2 C.1.2系的出现和表型特征。
237.In vivo imaging of invasive aspergillosis with 18F-fluorodeoxysorbitol positron emission tomography.
18F-氟脱氧山梨醇正电子发射断层扫描对侵袭性曲霉病的体内成像。
238.Angular and linear speed cells in the parahippocampal circuits.
海马旁回路中的角度和线性速度细胞。
239.Glyco-Decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation.
Glyco-Decipher使糖数据库独立于肽的匹配和特定位点N-糖基化的深入特征。
240.Collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium.
万古霉素耐药肠球菌对胸腺素的附带敏感性。
241.Reshuffling of the ancestral core-eudicot genome shaped chromatin topology and epigenetic modification in Panax.
祖先核心植物基因组的重新排列塑造了三七的染色质拓扑结构和表观遗传修饰。
242.Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19.
用于治疗COVID-19的SARS-CoV-2 3CL蛋白酶的优化药样小分子抑制剂的开发。
243.Asymmetric structure of the native Rhodobacter sphaeroides dimeric LH1–RC complex.
原生的红豆菌二聚体LH1-RC复合物的不对称结构。
244.Enhancing biofuels production by engineering the actin cytoskeleton in Saccharomyces cerevisiae.
通过在酿酒酵母中设计肌动蛋白细胞骨架来加强生物燃料的生产。
245.MiDAS 4: A global catalogue of full-length 16S rRNA gene sequences and taxonomy for studies of bacterial communities in wastewater treatment plants.
MiDAS 4：一个用于研究污水处理厂细菌群落的全长16S rRNA基因序列和分类法的全球目录。
246.Modification of BRCA1-associated breast cancer risk by HMMR overexpression.
HMMR过量表达对BRCA1相关乳腺癌风险的修饰。
247.DNA methylation in newborns conceived by assisted reproductive technology.
通过辅助生殖技术孕育的新生儿的DNA甲基化。
248.Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy.
病毒编程的细胞外囊泡使癌细胞对溶瘤病毒和小分子疗法敏感。
249.A universal deep neural network for in-depth cleaning of single-cell RNA-Seq data.
用于深入清理单细胞RNA-Seq数据的通用深度神经网络。
250.A genetic toolkit and gene switches to limit Mycoplasma growth for biosafety applications.
限制支原体生长的遗传工具箱和基因开关，用于生物安全应用。
251.FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice.
FGF21是蛋白质限制延长寿命和改善雄性小鼠代谢健康的必要条件。
252.A robust and interpretable machine learning approach using multimodal biological data to predict future pathological tau accumulation.
利用多模态生物数据预测未来病理性tau累积的稳健和可解释的机器学习方法。
253.Introducing principles of synaptic integration in the optimization of deep neural networks.
在深度神经网络的优化中引入突触整合的原则。
254.CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity.
CHMP2A调控肿瘤对自然杀伤细胞介导的细胞毒性的敏感性。
255.The overwhelming role of ballistic photons in ultrasonically guided light through tissue.
弹道光子在超声引导下穿过组织的压倒性作用。
256.CRISPR-mediated multiplexed live cell imaging of nonrepetitive genomic loci with one guide RNA per locus.
CRISPR介导的非重复性基因组位点的多重活细胞成像，每个位点只有一个引导RNA。
257.Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis.
C型凝集素受体Dectin-1的吞噬体信号是由膜内蛋白分解终止的。
258.Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery.
狼疮增强器风险变体通过合作的lncRNA和DNA甲基化机制导致IRF8的失调。
259.Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
PoxtA介导的对苯酚和噁唑烷酮类抗生素的抗性的结构基础。
260.Waffle Method: A general and flexible approach for improving throughput in FIB-milling.
华夫饼干法： 一种提高FIB研磨产量的通用和灵活的方法。
261.DNA sequence-dependent formation of heterochromatin nanodomains.
异染色质纳米域的DNA序列依赖性的形成。
262.Reply to: The overwhelming role of ballistic photons in ultrasonically guided light through tissue.
回应： 弹道光子在超声导引光穿过组织中的压倒性作用。
263.DELE1 tracks perturbed protein import and processing in human mitochondria.
DELE1追踪人类线粒体中扰乱的蛋白质导入和处理。
264.Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair.
Ca2+激活的鞘磷脂扰动和周转介导ESCRT-独立溶酶体修复。
265.Absolute measurement of cellular activities using photochromic single-fluorophore biosensors and intermittent quantification.
使用光致变色单萤光体生物传感器和间歇性定量法绝对测量细胞活动。
266.Elastic dosage compensation by X-chromosome upregulation.
通过X染色体上调进行弹性剂量补偿。
267.Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes.
来自非洲猿猴的人类疟疾寄生虫疟原虫的人畜共通起源。
268.Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.
磷酸肌苷驱动的反式自动磷酸化激活基本激酶PDK1.
269.Enhancement of prime editing via xrRNA motif-joined pegRNA.
通过xrRNA主题连接的pegRNA增强质粒编辑。
270.Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice.
线粒体靶向他莫昔芬减轻小鼠肥胖和2型糖尿病的标志物。
271.Citrullination of glucokinase is linked to autoimmune diabetes.
葡萄糖激酶的瓜氨酸化与自身免疫性糖尿病有关。
272.Predictive biomarkers for survival benefit with ramucirumab in urothelial cancer in the RANGE trial.
RANGE试验中拉莫西林单抗对尿道癌生存获益的预测性生物标志物。
273.Metal-responsive regulation of enzyme catalysis using genetically encoded chemical switches.
利用基因编码的化学开关对酶的催化作用进行金属响应性调节。
274.Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment.
肿瘤相关巨噬细胞的耗尽增强了局部和全身血小板介导的抗PD-1输送，用于手术后肿瘤复发治疗。
275.Direct measurements of mRNA translation kinetics in living cells.
活细胞中mRNA翻译动力学的直接测量。
276.STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming.
STAG2通过增强子环路重编程调控黑色素瘤中的干扰素信号。
277.Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation.
与Pro-macrobodies复合的LptDE转运体的低温电镜结构提供了对脂多糖转运的深入了解。
278.Cell-intrinsic Aryl Hydrocarbon Receptor signalling is required for the resolution of injury-induced colonic stem cells.
细胞内在的芳烃受体信号是解决损伤引起的结肠干细胞所必需的。
279.Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci.
携带百万碱基大小的人类免疫球蛋白基因组的反染色体小鼠高效的类人抗体复合物和杂交瘤生产。
280.Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
人类前序列蛋白酶的构象转换和底物识别机制的结构基础。
281.Neural structure of a sensory decoder for motor control.
用于运动控制的感觉解码器的神经结构。
282.Structure-based design of stabilized recombinant influenza neuraminidase tetramers.
基于结构设计的稳定化重组流感神经氨酸酶四聚体。
283.Structural basis for the SUMO protease activity of the atypical ubiquitin-specific protease USPL1.
非典型泛素特异性蛋白酶USPL1的SUMO蛋白酶活性的结构基础。
284.Mapping SP-C co-chaperone binding sites reveals molecular consequences of disease-causing mutations on protein maturation.
绘制SP-C协同伴侣的结合位点，揭示了致病突变对蛋白质成熟的分子后果。
285.Group testing via hypergraph factorization applied to COVID-19.
应用于COVID-19的超图因子化的群体测试。
286.Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes.
对非小细胞肺癌患者异种移植的综合分析确定了与患者预后相关的不同蛋白质类型。
287.Multiomic profiling of the acute stress response in the mouse hippocampus.
小鼠海马区急性应激反应的多组学分析。
288.acorde unravels functionally interpretable networks of isoform co-usage from single cell data.
acorde从单细胞数据中解读了功能上可解释的同构体共同使用网络。
289.In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration.
体内碱基编辑挽救了早发遗传性视网膜变性小鼠模型中的锥体光感受器。
290.Global field observations of tree die-off reveal hotter-drought fingerprint for Earth’s forests.
对树木死亡的全球实地观察揭示了地球森林更热的干旱指纹。
291.Ultraviolet optical horn antennas for label-free detection of single proteins.
用于无标签检测单一蛋白质的紫外光角天线。
292.RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells.
对跨膜p24贩运蛋白6和Clusterin有特异性的RNA诱导剂，用于定向输送成像试剂和RNA治疗剂到人类β细胞。
293.Auxiliary ATP binding sites support DNA unwinding by RecBCD.
辅助ATP结合位点支持RecBCD的DNA解旋。
294.SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress.
奖励途径中的SWI/SNF染色质重塑器复合物是行为适应压力的必要条件。
295.Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells.
谷胱甘肽依赖性氧化还原平衡描述了滤泡区和边缘区B细胞的不同代谢特性。
296.Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions.
全脑图谱显示，单一记忆的engrams分布在多个脑区。
297.The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
工程化的CD80变体融合疗法davoceticept将检查点拮抗与有条件的CD28成本刺激相结合，用于抗肿瘤免疫。
298.Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age.
小鼠星形细胞的可塑性确保了损伤后脑血管的持续内足覆盖，并随年龄增长而下降。
299.Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern.
300.Radiationless mechanism of UV deactivation by cuticle phenolics in plants.
301.The PripA-TbcrA complex-centered Rab GAP cascade facilitates macropinosome maturation in Dictyostelium.
302.Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling.
303.Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function.
304.Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing.
305.Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer.
306.Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression.
307.Immunosuppressive niche engineering at the onset of human colorectal cancer.
FPR2在识别Aβ42和人参蛋白的神经保护中的结构基础。
308.Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure.
单细胞和空间分析揭示了结直肠癌中FAP+成纤维细胞和SPP1+巨噬细胞的互动。
309.Deciphering spatial domains from spatially resolved transcriptomics with an adaptive graph attention auto-encoder.
BRG1缺失引起的非整倍体耐受性使染色体增加并恢复健康。
310.Current progress and open challenges for applying deep learning across the biosciences.
由MPK4和SUMM2介导的ROS平衡决定了协同细胞死亡。
311.The importance of biofilm formation for cultivation of a Micrarchaeon and its interactions with its Thermoplasmatales host.
生物膜形成对 Micrarchaeon 培养的重要性及其与其 Thermoplasmatales 宿主的相互作用。
312.Harnessing phosphonate antibiotics argolaphos biosynthesis enables a synthetic biology-based green synthesis of glyphosate.
利用膦酸盐抗生素argolaphos 生物合成可以实现基于合成生物学的草甘膦绿色合成。
313.Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms.
发现定义骨髓增生性肿瘤中干扰素反应的信号反馈回路。
314.PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.
PI3Kγ 刺激一种高分子量形式的肌球蛋白轻链激酶，以促进骨髓细胞粘附和肿瘤炎症。
315.Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle.
长链神经酰胺是将脂肪毒性与骨骼肌内质网应激联系起来的细胞非自主信号。
316.Biological invasions facilitate zoonotic disease emergences.
生物入侵促进了人畜共患疾病的出现。
317.Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin.
FPR2 识别 Aβ42 和 humanin 神经保护的结构基础。
318.Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer.
单细胞和空间分析揭示了结直肠癌中 FAP+ 成纤维细胞和 SPP1+ 巨噬细胞的相互作用。
319.Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness.
由 BRG1 丢失引起的非整倍体耐受允许染色体获得和适应性恢复。
320.ROS homeostasis mediated by MPK4 and SUMM2 determines synergid cell death.
由 MPK4 和 SUMM2 介导的 ROS 稳态决定助细胞死亡。
321.Imaging vesicle formation dynamics supports the flexible model of clathrin-mediated endocytosis.
成像囊泡形成动力学支持网格蛋白介导的内吞作用的灵活模型。
322.Selective optogenetic control of Gq signaling using human Neuropsin.
使用人 Neuropsin 对 Gq 信号的选择性光遗传学控制。
323.Defining the early stages of intestinal colonisation by whipworms.
确定鞭虫肠道定植的早期阶段。
324.Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.
定量磷酸化蛋白质组学分析将 STK11IP 鉴定为 mTORC1 的溶酶体特异性底物，可调节溶酶体酸化。
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